Heritability of Stress-Ulcer Susceptibility in Rats

This study was designed to provide estimates of the degree to which stress-ulcer susceptibility in the rat is genetically determined; whether that characteristic is a dominant, intermediate, or recessive trait; and how many genic units may be necessary to account for the observed trait variability. Parental populations of Sprague-Dawley rats and animals of the sixth generation of a stress-ulcer-susceptible (SUS) strain were used to produce F1, F2, and B1, and B2 backcross generations. Analyses of the data on the severity of stress-ulcers that developed during 12 hr. of restraint indicated that: (1) over half the variability in stressulcer susceptibility is genetically determined, and (2) susceptibility is incompletely dominant over resistance to stress-ulceration

Backcrossing · Biology · Gene · Heritability · Strain (injury) · Trait · Animal Behavior and Welfare Studies · Genetics · Internal Medicine · Medicine