The Severity of Depressive Symptoms as an Independent Predictor of Sustained Virological Response During Treatment of Hepatitis C With Pegylated Interferon-α2a and Oral Ribavirin
Bibliographic Data
| ID | 19302957 |
|---|---|
| Authors | Tomasz Pawłowski (0000-0002-3997-609X, Medical University of Warsaw), Marek Radkowski (0000-0003-1808-679X, Medical University of Warsaw), Karol Perlejewski (0000-0002-3782-6442, Medical University of Warsaw), Tomasz Laskus (0000-0002-3552-0028, Medical University of Warsaw), Krzysztof Małyszczak (0000-0001-6295-2742, Medical University of Warsaw) |
| Year | 2024 |
| Volume | 86 |
| Issue | 2 |
| Pages | 124-128 |
| Publication date | 2024-02-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0000000000001274 |
| PMID | 38193776 |
| OpenAlex | W4390775807 |
| Language | EN |
| References cited | 31 |
BACKGROUND: Sustained virological response (SVR) is the best indicator of successful therapy for hepatitis C virus (HCV) infection. Patients with chronic HCV infection treated with pegylated interferon-α and ribavirin (PEG-IFN-α/RBV) can achieve SVR 56% of the time. OBJECTIVES: This study aimed to evaluate baseline predictors of SVR in patients treated with PEG-IFN-α/RBV for HCV chronic infection. METHODS: A total of 101 patients receiving PEG-IFN-α/RBV for chronic HCV infection participated in the prospective cohort study. Symptoms of depression were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) before the treatment. The multivariate regression analysis was applied to determine predictors of SVR. RESULTS: Of a total of 101 patients included, 99 patients reached the primary end point-24 weeks after completing treatment. After the initial analysis of probable predictive variables, the logistic analysis included age, sex, HCV genetic type, and MADRS score. The HCV genotype (odds ratio = 0.22 [confidence interval = 0.073-0.68, p = .008) and MADRS score (OR = 0.88 [confidence interval = 0.80-0.98), p = .013]) predicted an SVR outcome. CONCLUSIONS: The severity of depressive symptoms before treatment and HCV genotype are independent predictors of SVR
Cohort · Confidence interval · Depression (economics) · Hepatitis C · Hepatitis C virus · Logistic regression · Odds ratio · Pegylated interferon · Prospective cohort study · Ribavirin · Virus · Cardiac Health and Mental Health · Diabetes Management and Education · Gastroenterology · Hepatitis C virus research · Immunology · Internal Medicine · Medicine
| Highly cited | No |
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