Endothelial Function and Hemodynamic Responses During Mental Stress

Bibliographic Data

ID19303149
AuthorsAndrew Sherwood (0000-0001-9067-185X, University of North Carolina at Chapel Hill), Kristy Johnson, Kristy S Johnson (University of North Carolina at Chapel Hill), James A Blumenthal (0000-0003-3789-0935, University of North Carolina at Chapel Hill), Alan L Hinderliter (0000-0002-3262-5668, University of North Carolina at Chapel Hill)
Year1999
Volume61
Issue3
Pages365-370
Publication date1999-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-199905000-00017
PMID10367618
OpenAlexW1972418645
LanguageEN
Citations received11
References cited25

OBJECTIVE: The hemodynamic basis of blood pressure responses during psychological stress shows striking individual differences that share an interesting similarity with risk for cardiovascular disease. Factors accounting for these individual differences are poorly understood. The present study examined the relationship of vascular endothelial function to stress-induced hemodynamic responses. METHODS: Subjects were 40 healthy men and women, aged 25 to 44 years. Hemodynamic responses were assessed during exposure to a battery of four diverse laboratory stressors. Endothelium-dependent arterial dilation (EDAD) was measured by ultrasound imaging of the brachial artery in response to reactive hyperemia. RESULTS: High EDAD response was associated with lower resting systolic (p < .01) and diastolic blood pressure (p < .05). EDAD response was unrelated to blood pressure responses during stress. However, systemic vascular resistance responses during laboratory stress were significantly greater (p < .02) for individuals with low EDAD responses. CONCLUSIONS: Exaggerated systemic vascular resistance responses during stress may reflect endothelial dysfunction. This association may help explain the growing evidence of a relationship between stress hemodynamics and cardiovascular disease risk. The nature of this association is discussed in terms of a possible interplay between the sympathetic nervous system and the endothelium in regulation of vascular tone

Blood flow · Blood pressure · Brachial artery · Cardiology · Endothelial Dysfunction · Endothelium · Hemodynamics · Reactive hyperemia · Stressor · Sympathetic nervous system · Vascular resistance · Cardiovascular Health and Disease Prevention · Clinical Psychology · Internal Medicine · Medicine · Nitric Oxide and Endothelin Effects · Psychology · Stress Responses and Cortisol

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