Effects of SKF #501 (N-9-Fluorenyl N, N-Ethyl-Beta-Chloroethylamine) on Cardiovascular Manifestations of Hypoglycemia Following Administration of Insulin

vere hypoglycemic reactions by means of in-sulin is a common procedure in the treatment of patients with psychoses. Ambulatory treat-ment in the home or office, employing smaller doses of insulin to produce milder reactions, has also been found of value in the handling of patients with, severe psychoneuroses ( i). Insulin therapy is limited to some extent in that it is contraindicated in patients with overt heart disease or those suspected of having coronary arterial disease. The release of epi-nephrine consequent to hypoglycemia may increase cardiac work to a dangerous degree or may give rise to myocardial damage in such individuals C2)- As a consequence of these facts, many persons whose mental status might be helped by insulin hypoglycemia are unable to undergo this treatment. If agents were available which neutralized the potentially harmful effects of endogenous epinephrine on the circulatory system—the increases in blood pressure, heart rate, pulse pressure, and cardiac output—the safe use of insulin therapy in elderly or cardiac patients would be possible. The availability of so-called "adrenolytic " or "sympatholytic " drugs such as dibenamine (N, N-dibenzyl-/?-chloro

Administration (probate law) · Anesthesia · BETA (programming language) · Hypoglycemia · Insulin · Computer Science · Diabetes Management and Research · Endocrinology · Hyperglycemia and glycemic control in critically ill and hospitalized patients · Internal Medicine · Medicine · Pharmacology