Responses to Controlled Diesel Vapor Exposure Among Chemically Sensitive Gulf War Veterans

OBJECTIVE: A significant proportion of Gulf War veterans (GWVs) report chemical sensitivity, fatigue, and unexplained symptoms resulting in ongoing disability. GWVs frequently recall an association between diesel and petrochemical fume exposure and symptoms during service. The purpose of the present study among GWVs was to evaluate the immediate health effects of acute exposure to chemicals (diesel vapors with acetaldehyde) with and without stress. METHODS: In a single, controlled exposure to 5 parts per million (ppm) diesel vapors, symptoms, odor ratings, neurobehavioral performance, and psychophysiologic responses of 12 ill GWVs (GWV-I) were compared with 19 age- and gender-matched healthy GWVs (GWV-H). RESULTS: Relative to baseline and to GWV-H, GWV-I reported significantly increased symptoms such as disorientation and dizziness and displayed significantly reduced end-tidal CO(2) just after the onset of exposure. As exposure increased over time, GWV-I relative to GWV-H reported significantly increased symptoms of respiratory discomfort and general malaise. GWV-I were also physiologically hyporeactive in response to behavioral tasks administered during but not before exposure. CONCLUSIONS: Current symptoms among GWV-I may be exacerbated by ongoing environmental chemical exposures reminiscent of the Gulf War. Both psychologic and physiologic mechanisms contribute to current symptomatic responses of GWV-I

Gulf war · Multiple chemical sensitivity · Odor · Psychiatry · Fibromyalgia and Chronic Fatigue Syndrome Research · History · Medicine · Psychology · Sleep and Work-Related Fatigue · Traumatic Brain Injury Research

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  Michael O Wirth, Thomas Ritz et al.•Psychosomatic Medicine•2006

  Añadir item

• The Chronic Fatigue Syndrome

  Open Access•Keiji Fukuda, STEPHEN E STRAUS et al.•Annals of Internal Medicine•1994

  Añadir item

• Hypothalamic-Pituitary-Adrenal Axis Reactivity in Chronic Fatigue Syndrome and Health Under Psychological, Physiological, and Pharmacological Stimulation

  Jens Gaab•Psychosomatic Medicine•2002

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• Relationship of Psychiatric Status to Gulf War Veterans' Health Problems

  Jessica Wolfe, Susan P Proctor et al.•Psychosomatic Medicine•1999

  Añadir item

• Cardiovascular Stress Responses and Their Relation to Symptoms in Gulf War Veterans With Fatiguing Illness

  Arnold Peckerman, John J LaManca et al.•Psychosomatic Medicine•2000

  Añadir item

• A Controlled Comparison of Multiple Chemical Sensitivities and Chronic Fatigue Syndrome

  John K Crellin, Nancy Fiedler et al.•Psychosomatic Medicine•1996

  Añadir item

• Psychological Differences Between Veterans With and Without Gulf War Unexplained Symptoms

  Daniel Storzbach, Keith A Campbell et al.•Psychosomatic Medicine•2000

  Añadir item

• The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome

  Simon Wessely, Trudie Chalder et al.•American Journal of Public Health•1997

  Añadir item

• Measuring chemical sensitivity prevalence

  Howard M Kipen, William K Hallman et al.•American Journal of Public Health•1995

  Añadir item