Living Alone and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

Bibliographic Data

ID19304968
AuthorsWengen Zhu (0000-0002-1280-0158, Fundación Juan March), Yuzhong Wu (0000-0001-7372-9239, Fundación Juan March), Yuanyuan Zhou (0000-0001-8378-6296, Fundación Juan March), Weihao Liang (0000-0001-9601-9184, Fundación Juan March), Ruicong Xue (0000-0001-9595-7785, Fundación Juan March), Zexuan Wu (0000-0003-3726-773X, Fundación Juan March), Dexi Wu (0000-0001-6674-5214, Fundación Juan March), Jiangui He (Fundación Juan March), Yugang Dong (0000-0002-3072-5040, Fundación Juan March, corresponding author), Chen Liu (0000-0001-6563-7975, Fundación Juan March, corresponding author)
Year2021
Volume83
Issue5
Pages470-476
Publication date2021-06-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000945
PMID33901053
OpenAlexW3158167237
LanguageEN
Citations received3
References cited24

OBJECTIVE: In patients with heart failure with preserved ejection fraction (HFpEF), whether living alone could contribute to a poor prognosis remains unknown. We sought to investigate the association of living alone with clinical outcomes in patients with HFpEF. METHODS: Symptomatic patients with HFpEF with a follow-up of 3.3 years (data collected from August 2006 to June 2013) in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial were classified as patients living alone and those living with others. The primary outcome was defined as a composite of cardiovascular death, aborted cardiac arrest, or HF hospitalization. RESULTS: A total of 3103 patients with HFpEF were included; 25.2% of them were living alone and were older, predominantly female, and less likely to be White and have more comorbidities compared with the other patients. After multivariate adjustment for confounders, living alone was associated with increased risks of HF hospitalization (hazard ratio [HR] = 1.29, 95% confidence interval [CI] = 1.03-1.61) and any hospitalization (HR = 1.26, 95% CI = 1.12-1.42). A significantly increased risk of any hospitalization (HR = 1.16, 95% CI = 1.01-1.34) was also observed in the Americas-based sample. In addition, each year increase in age, female sex, non-White race, New York Heart Association functional classes III and IV, dyslipidemia, and chronic obstructive pulmonary disease were independently associated with living alone. CONCLUSIONS: We assessed the effect of living arrangement status on clinical outcomes in patients with HFpEF and suggested that living alone was associated with an independent increase in any hospitalization.Clinical Trial Registration: ClinicalTrials.gov identifier: NCT00094302

Cardiology · Confidence interval · Confounding · Ejection fraction · Hazard ratio · Heart failure · Heart failure with preserved ejection fraction · Cardiac Structural Anomalies and Repair · Cardiovascular Function and Risk Factors · Heart Failure Treatment and Management · Internal Medicine · Medicine

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