Association Between Panic Disorder and Risk of Atrial Fibrillation

A Nationwide Study

Bibliographic Data

ID19305147
AuthorsYa-Fen Cheng (Taipei Veterans General Hospital), Hsin-Bang Leu, Hsin‐Bang Leu (0000-0001-6832-3234), Ching-Chieh Su, Chin-Chou Huang, Chia-Hung Chiang, Po-Hsun Huang, Po‐Hsun Huang (0000-0003-1584-6749), Chia-Min Chung, Chia‐Min Chung (0000-0003-1759-2279), Shing-Jong Lin, Shing‐Jong Lin, Jaw-Wen Chen, Jaw‐Wen Chen (0000-0002-7178-2316), Wan-Leong Chan, Wan‐Leong Chan (corresponding author)
Year2013
Volume75
Issue1
Pages30-35
Publication date2013-01-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0b013e318273393a
PMID23107841
OpenAlexW2326643565
LanguageEN
Citations received1
References cited29

OBJECTIVE: The aim of the present study was to investigate the association between panic disorder (PD) and atrial fibrillation (AF). METHODS: We used a nationwide population-based data set from Taiwan. A total of 3888 patients with PD and without a diagnosis of AF from a sampled cohort data set of 1,000,000 were included in the study group. Ten people without PD and AF were selected for every 1 patient in the study group, matched by propensity score matching according to time of enrollment, age, sex, and comorbidities. We performed log-rank tests to analyze differences in accumulated AF-free survival rates between the two groups. Cox proportional hazard regressions were performed to evaluate the independent factors determining the longitudinal hazard of AF. RESULTS: During a maximal 7-year follow-up, 48 patients from the study group (1.2% of the patients with PD) and 358 from the control group (0.9% of the patients without PD) were newly diagnosed as having AF. Patients with PD had a significantly higher incidence of AF (hazard ratio [HR] = 1.54 [1.14-2.09]; log-rank test, p = .004). After Cox model adjustment for risk factors and comorbidities, PD (HR = 1.73, 95% confidence interval [CI] = 1.26-2.37), age (HR = 1.07, 95% CI = 1.06-1.08), male sex (HR = 1.26, 95% CI = 1.03-1.55), hypertension (HR = 2.00, 95% CI = 1.55-2.56), history of coronary artery disease (HR = 1.45, 95% CI = 1.15-1.82), congestive heart failure (HR = 2.46; 95% CI, 1.84-3.30), and valvular heart disease (HR = 2.83, 95% CI = 1.85-4.42) were independently associated with increased risk of AF. CONCLUSIONS: PD is independently associated with higher incidence of AF to be diagnosed in the future. Larger prospective studies or meta-analysis are suggested to confirm the findings

Atrial fibrillation · Cardiology · Cohort · Confidence interval · Coronary artery disease · Hazard ratio · Heart failure · Incidence (geometry) · Panic disorder · Population · Proportional hazards model · Psychiatry · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Atrial Fibrillation Management and Outcomes · Cardiac Health and Mental Health · Internal Medicine · Medicine

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