The Prospective Association of the Diurnal Cortisol Rhythm With Sleep Duration and Perceived Sleeping Problems in Preschoolers
The Generation R Study
Bibliographic Data
| ID | 19306154 |
|---|---|
| Authors | Nathalie S Saridjan (Erasmus MC), Desana Kocevska (0000-0003-0492-9602, Erasmus MC), Maartje P C M Luijk (0000-0002-2595-9512, Erasmus MC), Vincent W V Jaddoe (0000-0003-2939-0041, Erasmus MC), Frank C Verhulst (0000-0003-4871-2210, Erasmus MC), Henning Tiemeier (0000-0002-4395-1397, Erasmus MC, corresponding author) |
| Year | 2017 |
| Volume | 79 |
| Issue | 5 |
| Pages | 557-564 |
| Publication date | 2017-06-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0000000000000440 |
| PMID | 28570434 |
| OpenAlex | W2564860788 |
| Language | EN |
| Citations received | 3 |
| References cited | 46 |
OBJECTIVE: Cortisol, the end product of the hypothalamic-pituitary-adrenal axis, plays an important role in modulating sleep. Yet, studies investigating the association between diurnal cortisol rhythm and sleep patterns in young children are scarce. We tested the hypothesis that the diurnal cortisol rhythm is associated with shorter sleep duration and more sleep problems across early childhood. METHODS: This study was embedded in Generation R, a population-based cohort from fetal life onward. Parents collected saliva samples from their infant at five moments during day 1. In 322 infants aged 12 to 20 months, we determined the diurnal cortisol rhythm by calculating the area under the curve (AUC), the cortisol awakening response (CAR), and the diurnal slope. Sleep duration and sleep behavior were repeatedly assessed across ages of 14 months to 5 years. Generalized estimating equation models were used to assess related cortisol measures to sleep duration and sleep behavior. RESULTS: The diurnal cortisol slope and the CAR, but not the AUC, were associated with sleep duration across childhood. Children with flatter slopes and children with a more positive CAR were more likely to have shorter nighttime sleep duration (β per nmol/L/h slope = -0.12, 95% confidence interval = -0.19 to -0.05, p = .001; β per nmol/L CAR = -0.01, 95% confidence interval = -0.02 to 0.00, p = .04). Cortisol measures did not predict sleep problems. CONCLUSIONS: The present study suggests that a flatter diurnal cortisol slope and a more marked morning rise, which can indicate stress (or hypothalamic-pituitary-adrenal dysregulation), have a long-term association with sleep regulation
Area under the curve · Circadian rhythm · Cohort study · Confidence interval · Cortisol awakening response · Generation R · Hydrocortisone · Morning · Population · Rhythm · Sleep (system call) · Endocrinology · Internal Medicine · Medicine · Psychology · Sleep and related disorders · Sleep and Wakefulness Research · Stress Responses and Cortisol
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| Unique citing works | 3 |
|---|---|
| Citations per year | 0,38 |
| Citation span | 2018 - 2023 (6) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |