Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms

Results From the Young Finns Study

Bibliographic Data

ID19306179
AuthorsMarko Elovainio (0000-0002-1401-1910, Turku University of Applied Sciences, corresponding author), Mikko A Hurme (0000-0002-8614-1044, Turku University of Applied Sciences), Mikko Hurme (0000-0001-9064-4413), Markus Jokela (0000-0003-0117-0012, Turku University of Applied Sciences), Laura Pulkki-Råback (0000-0003-3242-4863, Turku University of Applied Sciences), Mika Kivimäki (0000-0002-4699-5627, Turku University of Applied Sciences), Mirka Hintsanen (0000-0003-2673-0901, Turku University of Applied Sciences), Taina Hintsa (0000-0003-3765-8343, Turku University of Applied Sciences), Terho Lehtimäki (0000-0002-2555-4427, Turku University of Applied Sciences), Jorma Viikari, Jorma S A Viikari (0000-0001-6452-010X, Turku University of Applied Sciences), Olli T Raitakari (0000-0001-9365-3702, Turku University of Applied Sciences), Liisa Keltikangas-Jarvinen (0000-0002-7977-3852, Turku University of Applied Sciences)
Year2012
Volume74
Issue7
Pages675-681
Publication date2012-09-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0b013e318266d0f5
PMID22929065
OpenAlexW2026512831
LanguageEN
Citations received2
References cited43

OBJECTIVE: To examine whether the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in serotonin production, is associated with depressive symptoms. METHODS: The participants were 544 women and 442 men (aged 24-39 years) from the population-based Young Finns Study who participated in a medical examination in 2001 (including IDO and depression) and 2007 (follow-up assessment for depression). RESULTS: At baseline, IDO was associated with depressive symptoms (in the total cohort: B = 0.23, p < .001; women: B = 0.20, p = .007; men: B = 0.29, p = .002; p for interaction = .19). IDO at baseline was also associated with depressive symptoms at follow-up in women (B = 0.17, p = .03), which remained significant when adjusting for any of the biologic and behavioral risk factors. Adjusting for body mass index attenuated the association by 6%. In the final model including all baseline variables, none of the risk factors (except for baseline depressive symptoms) were associated with depressive symptoms at follow-up. CONCLUSIONS: These data suggest that IDO activity may be a risk factor for future depression especially in women. IDO-induced alterations in serotonergic function may offer one biologic explanation to the well-established associations between inflammation and depression

Anxiety · Depressive symptoms · Indoleamine 2,3-dioxygenase · Psychiatry · Tryptophan · Biochemistry · Cardiac Health and Mental Health · Chemistry · Medicine · Stress Responses and Cortisol · Tryptophan and brain disorders

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