Acute Psychological Stress and Exercise and Changes in Peripheral Leukocyte Adhesion Molecule Expression and Density

Bibliographic Data

ID19306328
AuthorsMarion U Goebel (University of California San Diego), and Paul J Mills
Year2000
Volume62
Issue5
Pages664-670
Publication date2000-09-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-200009000-00010
PMID11020096
OpenAlexW2316239013
LanguageEN
Citations received7
References cited39

OBJECTIVE: This study examined the effects of acute psychological stress and exhaustive exercise on the expression and density of adhesion molecules (L-selectin, lymphocyte function antigen-1 [LFA-1], and intracellular adhesion molecule-1 [ICAM-1]) on monocytes, granulocytes, and lymphocytes. METHODS: Forty-five healthy volunteers performed a 15-minute public speaking task and a 15- to 18-minute bicycle ergometer challenge. RESULTS: In general, both the exercise and speaking tasks led to increases in the number of circulating leukocytes and lymphocyte subsets. The density of L-selectin (CD62L) on mixed lymphocytes and T lymphocytes was decreased in response to exercise (p values < .001). Both stressors led to an increased density of LFA-1 (CD11a) on mixed lymphocytes (p values < .01), whereas CD11a density on monocytes and granulocytes remained unchanged. ICAM-1 (CD54) density was unaffected, but the number of lymphocytes, monocytes, and granulocytes expressing CD54 increased in the circulation on both stressors. CONCLUSIONS: The data indicate that both psychological stress and exercise have significant effects on cellular expression of adhesion molecules on circulating leukocytes. Given the crucial role that adhesion molecules on circulating cells play in inflammation and disease, these findings may have clinical relevance in sympathetic nervous system-induced immune activation

Adhesion · CD11a · CD18 · Cell adhesion · Cell adhesion molecule · Immune system · Inflammation · Integrin alpha M · Intercellular Adhesion Molecule-1 · L-selectin · Lymphocyte · Lymphocyte homing receptor · Stressor · Adipokines, Inflammation, and Metabolic Diseases · Chemistry · Endocrinology · Exercise and Physiological Responses · Immunology · Internal Medicine · Medicine · Neuroscience · Psychology · Stress Responses and Cortisol

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