Childhood Maltreatment and Psychiatric Comorbidity in Immune-Mediated Inflammatory Disorders

Bibliographic Data

ID19306337
AuthorsAnthony Wan (University of Manitoba), Çharles N Bernstein (0000-0001-8041-3574, Calgary Laboratory Services), Lesley A Graff (0000-0002-0743-3189, Calgary Laboratory Services), Scott B Patten (0000-0001-9871-4041, Calgary Laboratory Services), Jitender Sareen (0000-0001-8573-6495, Calgary Laboratory Services), John D Fisk (0000-0003-3512-8015, Calgary Laboratory Services), James M Bolton (0000-0001-6319-5181, Calgary Laboratory Services), Carol Hitchon (0000-0001-5547-3268, Calgary Laboratory Services), James J Marriott (Calgary Laboratory Services), Ruth Ann Marrie (0000-0002-1855-5595, Calgary Laboratory Services, corresponding author)
Year2022
Volume84
Issue1
Pages10-19
Publication date2022-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000001025
PMID34654023
OpenAlexW3206604211
LanguageEN
Citations received2
References cited45

OBJECTIVE: To determine whether childhood maltreatment is associated with immune-mediated inflammatory disorders (IMIDs; multiple sclerosis [MS], inflammatory bowel disease [IBD], and rheumatoid arthritis [RA]). We further aimed to determine the relationship between maltreatment and psychiatric comorbidity in IMIDs and whether these relationships differed across IMID. METHODS: Six hundred eighty-one participants (MS, 232; IBD, 216; RA, 130; healthy controls, 103) completed a structured psychiatric interview to identify psychiatric disorders, and the Childhood Trauma Questionnaire to evaluate five types of maltreatment: emotional abuse, physical abuse, sexual abuse, emotional neglect, and physical neglect. We evaluated associations between maltreatment, IMID, and psychiatric comorbidity using multivariable logistic regression models. RESULTS: The prevalence of having ≥1 maltreatment was similar across IMID but higher than in controls (MS, 63.8%; IBD, 61.6%; RA, 62.3%; healthy controls, 45.6%). Emotional abuse was associated with having an IMID (adjusted odds ratio [aOR] = 2.37; 1.15-4.89). In the sex-specific analysis, this association was only present in women. History of childhood maltreatment was associated with a lifetime diagnosis of a psychiatric disorder in the IMID cohort (OR = 2.24; 1.58-3.16), but this association did not differ across diseases. In those with IMID, total types of maltreatments (aOR = 1.36; 1.17-1.59) and emotional abuse (aOR = 2.64; 1.66-4.21) were associated with psychiatric comorbidity. CONCLUSIONS: Childhood maltreatment is more common in IMID than in a healthy population and is associated with psychiatric comorbidity. Given the high burden of psychiatric disorders in the IMID population, clinicians should be aware of the contribution of maltreatment and the potential need for trauma-informed care strategies

Comorbidity · Epidemiology of child psychiatric disorders · Poison control · Population · Psychiatric comorbidity · Suicide prevention · Child Abuse and Related Trauma · Child Abuse and Trauma · Tryptophan and brain disorders