Plasma Endothelin-1 Release During Acute Stress
Role of Ethnicity and Sex
Bibliographic Data
| ID | 19306384 |
|---|---|
| Authors | Frank A Treiber (0000-0001-5495-4131, Augusta University), Gaston K Kapuku, Gaston Kapuku (0000-0002-0854-1413, Augusta University), Harry Davis (0009-0002-7885-7832, Augusta University), Jennifer S Pollock (0000-0003-1956-0449, Augusta University), David M Pollock (0000-0002-0233-2362, Augusta University) |
| Year | 2002 |
| Volume | 64 |
| Issue | 5 |
| Pages | 707-713 |
| Publication date | 2002-09-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/00006842-200209000-00002 |
| OpenAlex | W4232925401 |
| Language | EN |
| Citations received | 2 |
| References cited | 21 |
Objectives The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress. Methods Two hundred twenty-two adolescents (mean age = 18.5 ± 2.8 years; 130 [70 males] EAs and 92 [48 males] AAs) completed two stressors (video game, forehead cold). Hemodynamic measures and blood samples were collected at catheter insertion and before and immediately after the two stressors, separated by 20-minute rest periods. Results AAs and males exhibited higher levels of SBP and DBP and of TPRI and ET-1 at each sampling point compared with EAs and females, respectively (p values < .001). AAs and males exhibited greater increases in SBP, TPRI, and ET-1 in response to each stressor (p values < .05). Intraindividual correlations between ET-1 and hemodynamic parameters revealed that most individuals exhibited a positive association between ET-1, BP, and TPRI. However, some individuals exhibited a negative association between ET-1 and the above-mentioned hemodynamics, suggesting a compensatory vasodilation mechanism. Conclusion The findings demonstrate significant sex and ethnicity differences in stress-induced vasoconstrictive peptide release and support the hypothesis that these differences may be important in explaining the ethnicity and sex differences in the prevalence of cardiovascular disease
Blood sampling · Hemodynamics · Stressor · Clinical Psychology · Endocrinology · Heart Rate Variability and Autonomic Control · Internal Medicine · Medicine · Nitric Oxide and Endothelin Effects · Physiology · Stress Responses and Cortisol
| Citations per year | 0.13 |
|---|---|
| Citation span | 2010 - 2014 (5) |
| Highly cited | No |