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Neuropsychological impairment in human immunodeficiency virus-infection

Implications for employment. HNRC Group. HIV Neurobehavioral Research Center

Bibliographic Data

ID19306388
AuthorsRobert K Heaton (0000-0001-8786-7480, University of California San Diego), Robert A Velin (University of California San Diego), J Allen McCutchan (0000-0001-9583-4531, University of California San Diego), Steven J Gulevich (University of California San Diego), J H Atkinson (University of California San Diego), Mark R Wallace (0000-0002-3163-1011, University of California San Diego), Henry P Godfrey (0000-0002-7195-6363, University of California San Diego), Donald Kirson (University of California San Diego), D A Kirson, Igor Grant (University of California San Diego)
Year1994
Volume56
Issue1
Pages8-17
Publication date1994-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-199401000-00001
PMID8197319
OpenAlexW1969632109
LanguageEN
Citations received12

Individuals infected with the human immunodeficiency virus-Type 1 (HIV-1), are at increased risk for neurobehavioral impairment, particularly in later stages of the disease. Even patients in the medically asymptomatic or minimally symptomatic stages of infection may show mild deficits on comprehensive neuropsychological (NP) test batteries, although the clinical significance of such deficits remains uncertain. The present study used vocational difficulties as markers of clinical significance of NP impairment. In a sample of 289 HIV-infected, nondemented men, those who evidenced NP impairment had a higher unemployment rate (p < .001) than did their unimpaired counterparts. In HIV-positive subjects who remained employed, NP impairment was strongly associated with subjective decreases in job-related abilities. Neither depression nor medical symptoms could explain the relationship between the NP impairment and employment problems. These results are consistent with previous studies investigating other neuropsychiatric disorders, which suggest that even mild NP impairment can interfere with employment status. From this standpoint, such impairment in HIV-infected persons may be described as "clinically significant."

Asymptomatic · Clinical significance · Cognition · Depression (economics) · Disease · Human immunodeficiency virus (HIV) · Neuropsychological test · Neuropsychology · Psychiatry · Autism Spectrum Disorder Research · Bipolar Disorder and Treatment · Clinical Psychology · Immunology · Internal Medicine · Medicine · Mosquito-borne diseases and control · Psychology

  • The Relationship Between Neuropsychological Functioning and Coping Activity Among HIV-Positive Men

    Open Access•Jennifer J Manly, Thomas L Patterson et al.•AIDS and Behavior•1997

  • Neurocognitive Deficits and Functional Outcome in Schizophrenia

    M F Green, Robert S Kern et al.•Schizophrenia Bulletin•2000

  • Changes in Neuropsychological Functioning with Progression of HIV-1 Infection

    Open Access•Teri T Baldewicz, Jane Leserman et al.•AIDS and Behavior•2004

  • Time allocation and disability in HIV infection

    Steven M Albert, George Todak et al.•Journal of Occupational Science•1994

  • Lifetime Methamphetamine Use Disorder and Reported Sleep Quality in Adults Living with HIV

    Open Access•Ni Sun-Suslow, Rowan Saloner et al.•AIDS and Behavior•2020

  • Relationships Between Dimensions of Disability Experienced by Adults Living with HIV

    Open Access•OHTN Cohort Study Team, Kelly K O’brien et al.•AIDS and Behavior•2012

  • Performances on the CogState and Standard Neuropsychological Batteries Among HIV Patients Without Dementia

    Open Access•Edgar T Overton, John S K Kauwe et al.•AIDS and Behavior•2011

  • United States National Trends in Mortality, Length of Stay (LOS) and Associated Costs of Cognitive Impairment in HIV Population from 2005 to 2014

    Open Access•Smit Patel, Neil U Parikh et al.•AIDS and Behavior•2018

  • Employment status is associated with both physical and mental health quality of life in people living with HIV

    Salvador Rueda, Sergio Rueda et al.•AIDS Care•2011

  • Back to work

    Marcus Lem, David Moore et al.•AIDS Care•2005

  • Predictors of Employment of Men With HIV/Aids

    Judith G Rabkin, Martin McElhiney et al.•Psychosomatic Medicine•2004

  • HIV/Aids and Employment Research

    Open Access•Liza M Conyers•The Counseling Psychologist•2008

Unique citing works12
Citations per year0,38
Citation span1994 - 2020 (27)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 12

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