Mechanisms Underlying the Association Between Early-Life Adversity and Physical Health
Charting a Course for the Future
Bibliographic Data
| ID | 19307016 |
|---|---|
| Authors | Newell Richard Bush (0000-0003-0217-9975, University of California, San Francisco, corresponding author), Nicole R Bush, Richard D Lane (0000-0002-4074-1407), Katie A Mclaughlin (0000-0002-1362-2410) |
| Year | 2016 |
| Volume | 78 |
| Issue | 9 |
| Pages | 1114-1119 |
| Publication date | 2016-11-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0000000000000421 |
| PMID | 27763991 |
| OpenAlex | W2533053448 |
| Language | EN |
| Citations received | 11 |
| References cited | 33 |
Early-life adversities (ELA) are associated with subsequent pervasive alterations across a wide range of neurobiological systems and psychosocial factors that contribute to accelerated onset of health problems and diseases. In this article, we provide an integrated perspective on recent developments in research on ELA, based on the articles published in this Special Issue of Psychosomatic Medicine . We focus on the following: 1) the distinction between specific versus general aspects of ELA with regard to the nature of exposure (e.g., physical and sexual abuse, emotional abuse or neglect, relative socioeconomic deprivation), biological and behavioral correlates of ELA, and differences across diseases; 2) the importance of timing in the critical phases of exposure to ELA; and 3) adaptive versus dysfunctional responses to ELA and their consequences for biological and behavioral risk factors for adverse health outcomes. This article concludes with outlining important new targets for research in this area, including the neurobiology of affect as a mechanism linking ELA to adverse health outcomes, and the need for large-scale longitudinal investigations of multisystem processes relevant to ELA in diverse samples, starting prenatally, continuing to late adolescence, and with long-term follow-up assessments that enable evaluation of incident disease outcomes
Association (psychology) · Developmental psychology · Disease · Dysfunctional family · Environmental health · Injury prevention · Life course approach · Neglect · Perspective (graphical) · Physical abuse · Poison control · Psychiatry · Psychosocial · Psychotherapist · Sexual abuse · Child Abuse and Trauma · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Early Childhood Education and Development · Medicine · Psychology
Conclusion
The role of early adverse experience and empathy in the prediction of pathological concern
Intergenerational educational mobility and mental health
Biased Competition Favoring Physical Over Emotional Pain
Socioeconomic Status and Cardiovascular Responses to Standardized Stressors
Assessing Lifetime Stress Exposure Using the Stress and Adversity Inventory for Adults (Adult STRAIN)
Emotion, Social Relationships, and Physical Health
Effects of Mindfulness-Based Stress Reduction on Experimental Pain Sensitivity and Cortisol Responses in Women With Early Life Abuse
Family Socioeconomic Status, Cortisol, and Physical Health in Early Childhood
Social mobility and mental health
Impact of family childhood adversity on risk of violence and involvement with police in adolescence
Beyond Cumulative Risk
Childhood adversity and neural development
Future Directions in Childhood Adversity and Youth Psychopathology
Brain on stress
Critical Periods in Speech Perception
Leveraging the biology of adversity to address the roots of disparities in health and development
Epigenetic Mediators Between Childhood Socioeconomic Disadvantage and Mid-Life Body Mass Index
Childhood Psychological Distress as a Mediator in the Relationship Between Early-Life Social Disadvantage and Adult Cardiometabolic Risk
Childhood Adversity and Pain Sensitization
Childhood Exposure to Violence and Chronic Physical Conditions in a National Sample of US Adolescents
Prediction of Postpartum Weight in Low-Income Mexican-Origin Women From Childhood Experiences of Abuse and Family Conflict
Prenatal Undernutrition and Autonomic Function in Adulthood
Maternal History of Childhood Abuse and Risk of Asthma and Allergy in 2-Year-Old Children
Psychophysiological Reactivity
Early-Life Experiences and Telomere Length in Adult Rhesus Monkeys
Dimensions of Adversity, Physiological Reactivity, and Externalizing Psychopathology in Adolescence
The Great Debate, Revisited
Dimensions of Socioeconomic Status and Childhood Asthma Outcomes
Prenatal Major Depressive Disorder, Placenta Glucocorticoid and Serotonergic Signaling, and Infant Cortisol Response
Socioeconomic Adversity, Negativity in the Parent Child-Relationship, and Physiological Reactivity
Childhood Bullying Victimization and Overweight in Young Adulthood
Beyond cumulative risk
Cumulative risk and child development
| Unique citing works | 11 |
|---|---|
| Citations per year | 1,38 |
| Citation span | 2018 - 2025 (8) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 11 |