Examining Antidepressant Use and Myocardial Infarction Risk in the Hunt Study

According to prenatal programming theory, maternal corticotropin-releasing hormone (pCRH), a peptide essential for fetal development and birth timing, may play a central role underlying the intergenerational transmission of stress. Empirical evidence is sparse, however. In a socioeconomically diverse sample of 838 mother-child pairs from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) cohort, Sullivan et al. found that exposure to maternal pCRH during pregnancy was unrelated to children’s anxiety and depression symptoms in middle childhood, regardless of fetal sex. Existing theories regarding the role of pCRH should be reevaluated alongside other prenatal psychobiological mechanisms, such as maternal inflammation or epigenetic processes. https://doi.org/10.1097/PSY.0000000000001478 Building on foundational stress-buffering paradigms, a laboratory study of 101 couples recasts stress physiology as inherently dyadic. Using the Trier Social Stress Test, Jacmin-Park et al. revealed sex-differentiated cortisol responses and a pattern in which sexual and gender diverse (SGD) couples exhibited lower post-stress cortisol in comparison with cisgender heterosexual couples. The findings elevate partner support from context to mechanism, positioning couple dynamics as a powerful regulator of physiological recovery. The novel finding that SGD couples showed better stress recovery than cisgender heterosexual couples extends prior research on the protective effects of community and social support among SGD individuals. https://doi.org/10.1097/PSY.0000000000001485 Childhood adversity may be a risk factor for higher pain in adulthood; however, it has been relatively unexplored in the context of breast cancer survivorship. Daang et al. examined the associations between childhood adversity and pain approximately 12 months after primary breast cancer treatment (n=175) and potential emotional and inflammatory mechanisms. Childhood adversity was positively associated with pain. This association was mediated by more ambivalence over emotional expression with higher adversity, but not by any of the inflammatory markers. https://doi.org/10.1097/PSY.0000000000001487 Cytomegalovirus (CMV) infection has been associated with poorer self-regulation in older adults, but its effects on daily processes of daily living, including stress, in younger adults has not been tested. In 113 young adults, Gloger et al. examined how CMV is associated with daily stress during young adulthood and if self-regulation traits played a role. Participants with CMV reported fewer stress exposures and lower stress severity only when trait goal pursuit was high. CMV may interact with self-regulation in a way that meaningfully affects individual differences in daily stress processes in young adults, thus playing a larger role in daily life and health in young adulthood than is currently recognized. https://doi.org/10.1097/PSY.0000000000001472 Somatic symptom disorder (SSD) involves distressing physical symptoms and can be diagnosed regardless of coexisting medical conditions. Wittenbecher et al. examined the role of somatic comorbidity in a prospective cohort of outpatients with SSD (n=241). Comorbidities were common (61%) and associated with older age and poorer physical health-related quality of life, but not with SSD severity or psychosocial characteristics. In contrast, health anxiety was strongly associated with more severe SSD. SSD proved a valid construct independent of medical illness and health anxiety showed promise as a clinically relevant treatment target. https://doi.org/10.1097/PSY.0000000000001483 A bidirectional Mendelian randomization study by Tong et al. investigated depression and musculoskeletal disorders using European and East Asian genome-wide association study data (n=636,987). Genetically predicted depression elevated neck-shoulder, hip, and knee pain risks, while these musculoskeletal disorders (plus back pain) elevated depression risk, but with no links to low back pain. These bidirectional relationships could inform clinical screening and management but need validation, increasing understanding of these genetic correlations. https://doi.org/10.1097/PSY.0000000000001474 Holle et al. tested whether people with atopic dermatitis showed an attentional bias towards disease-related or stigma-related words, a process that has been proposed to help maintain psychological distress in chronic conditions. The idea had been tested in psoriasis, but not in the context of atopic dermatitis. Across four preregistered experiments, patients with atopic dermatitis (N=133) showed no evidence of more attentional bias than matched controls. A general attentional hypervigilance account in atopic dermatitis was not observed, suggesting caution before prioritizing attention-bias-based interventions in this population or generalizing from similar conditions. https://doi.org/10.1097/PSY.0000000000001479 Consultation-liaison psychiatry (CLP) plays a key role in managing psychiatric comorbidities in general hospitals. In this retrospective study of 2070 patients referred to consultation-liaison psychiatry care from 2018 to 2022, Demesmaeker et al. found that earlier CLP intervention was associated with shorter length of stay. Referrals occurred more rapidly during 2020–2021, whereas delays were more frequent in surgical and intensive care units. Timely psychiatric consultation provided clinical and organization benefits. https://doi.org/10.1097/PSY.0000000000001484

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• Antidepressant Use and Risk of Myocardial Infarction

  Håvard R Karlsen, Maja-Lisa Løchen et al.•Psychosomatic Medicine•2023

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