The Interplay Between Stress and Fullness in Patients With Functional Dyspepsia and Healthy Controls

An Exploratory Experience Sampling Method Study

Bibliographic Data

ID19307473
AuthorsTim Klaassen (0000-0002-1519-4026, Maastricht University Medical Centre, corresponding author), Lisa Vork (0000-0001-7316-3191, Maastricht University), Fabiënne G M Smeets, Fabiënne G Smeets (0000-0002-1761-8312, Maastricht University), Freddy J Troost (0000-0002-0018-5557, Maastricht University), Joanna W Kruimel (0000-0001-7102-1720, Maastricht University), Carsten Leue (0000-0003-1553-5705, Maastricht University), Ad Am Masclee (0000-0001-5819-0116, Maastricht University), Ad A M Masclee, Daniel Keszthelyi (0000-0001-9856-9980, Maastricht University)
Year2022
Volume84
Issue3
Pages306-312
Publication date2022-04-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000001012
PMID34524263
OpenAlexW3201387409
LanguageEN
Citations received1
References cited36

OBJECTIVE: Fullness is a cardinal symptom in functional dyspepsia (FD). The use of real-time symptom assessment might provide more insight into factors, such as daily stress, that can influence fullness. Therefore, this study aimed to use the experience sampling method (a real-time, repeated-measurement method making use of repeated questionnaires available at random moments for a limited amount of time) to assess the association between stress and fullness in patients with FD and healthy controls (HCs). METHODS: Thirty-five patients with FD (25 female, mean age = 44.7 years) and 34 HCs (24 female, mean age = 44.1 years) completed the experience sampling method (a maximum of 10 random moments per day) for 7 consecutive days. Stress and fullness were rated on an 11-point Numeric Rating Scale. Data between patients with FD and HCs were statistically compared using a Student samples t test and linear mixed-effects models with repeated measures (level 1) nested within participants (level 2). RESULTS: Average fullness scores were 2.23 (standard error = 0.37) points higher in patients with FD compared with HCs (p < .001). Average stress scores were 1.37 (standard error = 0.30) points higher in patients with FD compared with HCs (p = .002).In FD, fullness scores increased with 0.14 for every 1-point increase in concurrent stress scores (p = .010). Fullness scores at t = 0 increased with 0.12 for every 1-point increase in stress scores at t = -1 (p = .019). T = 0 stress scores were not associated with change in t = -1 fullness scores. No associations between concurrent symptom scores were found for HCs. CONCLUSIONS: Concurrent and preceding stress scores are positively associated with fullness scores in patients with FD, but not in HCs. These findings indicate that increased levels of stress may precede feelings of fullness in patients with FD. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT04204421

Analysis of variance · Experience sampling method · Perceived Stress Scale · Physical therapy · Rating scale · Repeated measures design · Standard error · Statistics · Stress (linguistics) · Gastroesophageal reflux and treatments · Gastrointestinal motility and disorders · Internal Medicine · Mathematics · Medicine · Microscopic Colitis · Psychology

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