Type 2 Diabetes Among People With Posttraumatic Stress Disorder

Systematic Review and Meta-Analysis

Bibliographic Data

ID19307642
AuthorsDavy Vancampfort (0000-0002-4592-8625, The University of Sydney, corresponding author), Simon Rosenbaum (0000-0002-8984-4941, The University of Sydney), Philip B Ward (0000-0002-5779-7722, The University of Sydney), Zachary Steel (0000-0002-5048-2920, The University of Sydney), Oscar Lederman (0000-0002-0321-5723, The University of Sydney), Alice Veronica Lamwaka (The University of Sydney), Justin W Richards (The University of Sydney), Brendon Stubbs (0000-0001-7387-3791, The University of Sydney)
Year2016
Volume78
Issue4
Pages465-473
Publication date2016-05-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000297
PMID26867081
OpenAlexW2338348701
LanguageEN
Citations received7
References cited51

OBJECTIVE: To clarify the prevalence and predictors of Type 2 diabetes mellitus (T2DM) in people with posttraumatic stress disorder (PTSD) and where possible compare this to healthy controls. METHODS: We searched major electronic databases until May 2015 for studies reporting T2DM prevalence in people with PTSD. Two independent authors extracted data and completed methodological quality appraisal. A random-effects meta-analysis was used. RESULTS: From 1171 candidate publications after exclusions, nine publications were included (n = 23,396; 28.6% male; mean age = 35-60 years). The overall prevalence of T2DM was 10.0% (95% confidence interval [CI] = 8.1%-12.0%). Subgroup analysis demonstrated that war veterans experience higher prevalence of T2DM (16.3%; 95% CI = 5.2%-31.8%; n studies = 3, n = 473) compared with mixed samples (11.8%; 95% CI = 6.34-18.7, p < .001; n studies = 4, n = 2753). Increasing age (β = 0.0593, 95% CI = 0.010-0.109, z = 2.34, p = .019), median year of publication (β = -0.08, 95% CI = -0.14 to -0.03, z = -3.09, p = .002), and a lower percentage of white participants (β = -3.21, 95% CI = -5.12 to -1.29, z = -2.28, p = .001) predicted prevalence of T2DM. A relative risk meta-analysis comparing controls (n = 125,723) against those with PTSD (n = 23,203) demonstrated a significantly increased risk of T2DM (n studies = 5, relative risk = 1.49, 95% CI = 1.17-1.89, p = .001). CONCLUSIONS: People with PTSD are at a high risk for developing T2DM. The current findings should, however, be interpreted with caution because most studies were based on self-report data

Confidence interval · Diabetes mellitus · Meta-analysis · Posttraumatic stress · Psychiatry · Relative risk · Subgroup analysis · Type 2 Diabetes Mellitus · Demography · Diabetes Management and Education · Diabetes Management and Research · Endocrinology · Internal Medicine · Medicine · Posttraumatic Stress Disorder Research

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