Depressed Mood and Other Psychiatric Manifestations of Cushingʼs Syndrome

Relationship to Hormone Levels

Bibliographic Data

ID19308563
AuthorsMonica N Starkman (University of Michigan), David E Schteingart, Anthony Schork (University of Michigan), Anthony M Schork
Year1981
Volume43
Issue1
Pages3-18
Publication date1981-02-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-198102000-00002
PMID6259680
OpenAlexW1999790101
LanguageEN
Citations received8
References cited2

Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decreased libido and insomnia). A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level. The relationship of depressed mood and hormone levels was examined. Low ACTH levels were significantly associated with milder rather than pronounced depressed mood. The implications of the similarities in psychiatric manifestations between Cushing's syndrome and the primary affective disorders are discussed

Affect (linguistics) · Anxiety · Crying · Decreased Libido · Depression (economics) · Libido · Mood · Mood disorders · Psychiatry · Autoimmune Neurological Disorders and Treatments · Clinical Psychology · Endocrinology · Internal Medicine · Medicine · Pituitary Gland Disorders and Treatments · Psychology · Stress Responses and Cortisol

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