Well-Being and Arthritis Incidence

The Role of Inflammatory Mechanisms. Findings From the English Longitudinal Study of Ageing

Bibliographic Data

ID19308575
AuthorsJudith A Okely (0000-0002-2225-4066, Kleijnen Systematic Reviews (United Kingdom), corresponding author), Alexander Weiss (0000-0002-9125-1555, Kleijnen Systematic Reviews (United Kingdom)), Catharine R Gale (0000-0002-3361-8638, Kleijnen Systematic Reviews (United Kingdom))
Year2017
Volume79
Issue7
Pages742-748
Publication date2017-09-01
Open AccessYes
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000480
PMID28604559
OpenAlexW2626136229
LanguageEN
Citations received1
References cited43

OBJECTIVE: Higher levels of well-being are associated with lower levels of inflammatory markers in healthy populations; however, it is unclear whether this association translates into a reduced risk of disease. In the current study, we tested whether the association between well-being and inflammation results in a lower risk of arthritis. METHODS: The sample consisted of 5266 participants 50 years or older from the English Longitudinal Study of Ageing and included six waves of data collection. We used a structural equation modeling approach to test whether inflammatory markers (C-reactive protein [CRP] or fibrinogen) mediated the association between well-being and arthritis risk for a 10-year follow-up period. RESULTS: Higher levels of well-being were associated with a decrease in arthritis risk (hazard ratio = 0.97 per unit, 95% confidence interval = 0.96 to 0.98, p < .001). Of the two inflammatory markers, only CRP was associated with arthritis risk. Mediation analysis revealed that the indirect effect of well-being (at wave 1) on arthritis risk via CRP (at wave 2) was significant (hazard ratio = 0.996, 95% confidence interval = 0.995 to 0.998, p < .001). This effect remained significant after adjustment for demographic and health behavior variables and depressive symptoms. CONCLUSIONS: CRP accounts for a small proportion of the association between well-being and a reduced risk of arthritis

Arthritis · C-reactive protein · Confidence interval · Hazard ratio · Incidence (geometry) · Inflammation · Inflammatory arthritis · Mediation · Proportional hazards model · Adipokines, Inflammation, and Metabolic Diseases · Cardiac Health and Mental Health · Internal Medicine · Medicine · Rheumatoid Arthritis Research and Therapies

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