Association Between Depression and Inflammation-Differences by Race and Sex
The Meta-Health Study
Bibliographic Data
| ID | 19308676 |
|---|---|
| Authors | Alanna A Morris (0000-0002-8033-3707, Emory University), Liping Zhao (0000-0002-7682-9339, NCR (United States)), Yusuf Ahmed (0000-0003-3932-0215, NCR (United States)), Neli Stoyanova (0009-0000-6812-8658, NCR (United States)), Christine De Staercke (0000-0002-7722-5705, NCR (United States)), William Craig Hooper, Gary H Gibbons (NCR (United States)), Gary Gibbons, Rebecca Din-Dzietham, Rebecca Din‐dzietham (NCR (United States)), Arshed Quyyumi, Anurag Mehta (0000-0002-6910-5551, NCR (United States)), Viola Vaccarino (0000-0002-9054-0654, NCR (United States)) |
| Year | 2011 |
| Volume | 73 |
| Issue | 6 |
| Pages | 462-468 |
| Publication date | 2011-07-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e318222379c |
| PMID | 21715300 |
| PMCID | PMC3951048 |
| OpenAlex | W1986528066 |
| Language | EN |
| Citations received | 8 |
| References cited | 40 |
OBJECTIVE: To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined whether the association differs by race and sex. METHODS: Depressive symptoms and CRP were assessed in 512 African American and white participants, age 30 to 65 years, as part of the community-based Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) Study. Depression was determined by responses to the Beck Depression Inventory II (BDI-II). Multivariable linear regression models were used to adjust for demographic and metabolic risk factors. RESULTS: African American men had higher total BDI-II scores than white men (p = .03), whereas there was no difference in women. There was a significant race-sex-depression interaction in predicting CRP levels (p = .02). White women with mild to severe depressive symptoms had higher levels of CRP compared with those with minimal to no depressive symptoms (p < .05). There were no differences in levels of CRP by severity of depressive symptoms in white men or African Americans of either sex. Higher BDI-II scores were related to higher CRP levels in white women after adjusting for age and level of education (β = 0.227, p = .006). However, the association was eliminated after further adjustment for metabolic risk factors (β = 0.077, p = .35). CONCLUSIONS: Although depressive symptoms are associated with inflammation, the association varies by race and sex
African american · Anxiety · Association (psychology) · Beck Depression Inventory · Biology · C-reactive protein · Depression (economics) · Depressive symptoms · Inflammation · Psychiatry · Race (biology) · Cardiac Health and Mental Health · Demography · Internal Medicine · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders
Religious Involvement, Racial/Ethnic Disparities, and Depression
Disentangling depression in women with diabetes
The Association Between Depression and Leptin Is Mediated by Adiposity
Effect of Meditation on Endothelial Function in Black Americans With Metabolic Syndrome
Immunocognitive Model of Depression Secondary to Anxiety in Adolescents
Association between C-reactive protein and mood disorder in a representative sample of the Canadian population
The Identity Vitality-Pathology model
Prospective data from the Women's Health Initiative on depressive symptoms, stress, and inflammation
From inflammation to sickness and depression
Comparison of Beck Depression Inventories-IA and-II in Psychiatric Outpatients
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Inflammation and Its Discontents
Sex, Race/Ethnicity, Socioeconomic Status, and BMI in Relation to Self‐Perception of Overweight
Markers of Inflammation and Cardiovascular Disease
The Pittsburgh sleep quality index
Clinical Presentations of Depression in African American and White Outpatients
Relationship Between Depression and C-Reactive Protein in a Screening Population
Association Between Depression and Elevated C-Reactive Protein
Depressive Symptoms, Race, and Circulating C-Reactive Protein
C-Reactive Protein Is Associated With Psychological Risk Factors of Cardiovascular Disease in Apparently Healthy Adults
Associations Between Depressive Symptoms and Inflammatory/Hemostatic Markers in Women During the Menopausal Transition
Depression and C-Reactive Protein
Associations of Depression With C-Reactive Protein, IL-1, and IL-6
A Comparison Of Depressive Symptons In African Americans And Caucasian Americans
| Unique citing works | 8 |
|---|---|
| Citations per year | 0,57 |
| Citation span | 2012 - 2026 (15) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 7 |