Chronic Mild Stress–Induced Depression-Like Symptoms in Rats and Abnormalities in Catecholamine Uptake in Small Arteries

Bibliographic Data

ID19309260
AuthorsElena V Bouzinova (0000-0001-9511-8009, Aarhus University Hospital), Nina Møller-Nielsen, Nina Marie Møller-Nielsen, Donna Briggs Boedtkjer (0000-0003-1736-3484), Torbjoern Broegger, Ove Wiborg (0000-0002-0555-2811), Christian Aalkjaer (0000-0003-2618-4015), Vladimir V Matchkov (0000-0002-3303-1095, corresponding author)
Year2012
Volume74
Issue3
Pages278-287
Publication date2012-04-01
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0b013e31824c40a9
PMID22408132
OpenAlexW2057316805
LanguageEN
Citations received2
References cited61

OBJECTIVE: Major depression and cardiovascular diseases have a strong comorbidity; however, the reason for this is unknown. In the chronic mild stress (CMS) model of depression, only a fraction of rats develop a major feature of depression-anhedonia-like behavior, whereas other rats are stress resilient. Previous studies suggested that CMS rats also have increased total peripheral vascular resistance. METHODS: On the basis of CMS-induced changes of sucrose intake, a reliable measure for anhedonia, rats were divided into "resilient" and "anhedonic" groups. An interaction between hedonic status and vascular function was studied after 4 and 8 weeks of CMS exposure in vitro in wire myograph on saphenous arteries and mesenteric small arteries (MSAs) from these rats. RESULTS: When comparing the different experimental rat groups, arterial sensitivities to noradrenaline (NA) were similar under control conditions, but in the presence of the neuronal reuptake inhibitor cocaine, arteries from anhedonic rats were more sensitive to NA. No change in perivascular innervation was found, but elevated expression of neuronal NA transporter was detected. Inhibition of extraneuronal uptake with corticosterone (1 μM) suggests that this transport is diminished in MSAs after CMS. The corticosterone-sensitive transporter organic cation cotransporter 2 was shown to be reduced in MSAs after CMS. No CMS-induced changes in the corticosterone-sensitive transport were found in saphenous arteries. CONCLUSIONS: Our results indicate that CMS-induced depression-like symptoms in rats are associated with changes in catecholamine uptake pathways in the vascular wall, which potentially modulates the effect of sympathetic innervation of resistance arteries

Artery · Cardiology · Catecholamine · Chronic stress · Coronary arteries · Depression (economics) · Cardiac Health and Mental Health · Internal Medicine · Medicine · Neurotransmitter Receptor Influence on Behavior · Stress Responses and Cortisol

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