Pathways Linking Major Depression and Immunity in Ambulatory Female Patients

Bibliographic Data

ID19309372
AuthorsGale E Miller (0000-0002-7217-1082, Carnegie Mellon University), Gregory E Miller, Sheldon Cohen (0000-0003-2248-4600, Carnegie Mellon University), Tracy B Herbert (Carnegie Mellon University)
Year1999
Volume61
Issue6
Pages850-860
Publication date1999-11-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/00006842-199911000-00021
PMID10593638
OpenAlexW2082179949
LanguageEN
Citations received21
References cited43

OBJECTIVES: The goals of this study were to investigate whether depression is associated with cellular immunity in ambulatory patients and to identify neuroendocrine and behavioral pathways that might account for this relationship. METHODS: We studied 32 women who met Diagnostic and Statistical Manual of Mental Disorder, fourth edition, criteria for major depressive disorder and 32 healthy female control subjects. The groups were matched for age and ethnicity. None were taking medication, and all were free of disease involving the immune system. RESULTS: Depressed subjects had reduced proliferative responses to the mitogens concanavalin A and phytohemagglutinin compared with control subjects. Natural killer cell activity was reduced among older depressed subjects but enhanced among younger depressed subjects. Although depression was associated with elevated circulating levels of norepinephrine and estradiol, these hormones could not account for the immunologic differences between depressed and control subjects. Depression was also associated with greater tobacco and caffeine consumption, less physical activity, and poorer sleep quality. Mediational analyses were consistent with physical activity acting as a pathway through which depression was associated with reduced lymphocyte proliferation. CONCLUSIONS: Ambulatory patients with mild to moderately severe depression exhibit reduced mitogen-stimulated lymphocyte proliferative responses and altered natural killer cell cytotoxicity. The relationship between depression and proliferative responses may be mediated by physical activity

Ambulatory · Anxiety · Cellular immunity · Depression (economics) · Hormone · Immune system · Immunity · Lymphocyte · Psychiatry · Psychoneuroimmunology · Cardiac Health and Mental Health · Endocrinology · Immunology · Internal Medicine · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders