Risk of Epilepsy in Individuals With Posttraumatic Stress Disorder

A Nationwide Longitudinal Study

Bibliographic Data

ID19309530
AuthorsYu-Hsiung Chen (0000-0002-7762-2532, National Yang Ming Chiao Tung University, corresponding author), Han-Ting Wei (Bridge University), Ya‐Mei Bai (0000-0003-3779-9074, Bridge University), Ya-Mei Bai, Ju-Wei Hsu (Bridge University), Kai-Lin Huang (Bridge University, corresponding author), Tung-Ping Su, Tung‐Ping Su (0000-0002-9049-8935, Bridge University), Cheng‐Ta Li (0000-0002-0670-1153, Bridge University, corresponding author), Cheng-Ta Li, Wei-Chen Lin (0000-0001-7223-5931, Bridge University, corresponding author), Yi-Hui Wu, Yi‐Hui Wu (0000-0002-8657-6371, Bridge University), Tai-Long Pan, Tai‐Long Pan (0000-0002-0187-8689, Bridge University), Tzeng‐Ji Chen (0000-0002-8350-0232, Bridge University, corresponding author), Tzeng-Ji Chen, Shih‐Jen Tsai (0000-0002-9987-022X, Bridge University), Shih-Jen Tsai, Mu‐Hong Chen (0000-0001-6516-1073, Bridge University, corresponding author), Mu-Hong Chen
Year2017
Volume79
Issue6
Pages664-669
Publication date2017-07-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenuePsychosomatic Medicine (JOURNAL)
Journal identifiersISSN: 0033-3174 • E-ISSN: 1534-7796
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/psy.0000000000000463
PMID28306623
OpenAlexW2595446788
LanguageEN
Citations received1
References cited36

OBJECTIVE: Several cross-sectional studies have reported a relationship between posttraumatic stress disorder (PTSD) and epilepsy. However, the temporal association between PTSD and epilepsy has rarely been investigated. We hypothesized that the risk of developing epilepsy later in life would be higher in patients with PTSD than in those without PTSD. METHODS: Using the Taiwan National Health Insurance Research Database, 6425 individuals with PTSD and 24,980 age-/sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Those who developed epilepsy during the follow-up period were identified. RESULTS: Individuals with PTSD had a higher incidence of developing epilepsy (2.65 versus 0.33 per 1000 person-years, p < .001), with an earlier onset of epilepsy (37.53 years [15.80 years] versus 48.11 years [23.97 years], p = .002) than did the controls. Individuals with PTSD had an elevated risk of developing epilepsy (hazard ratio [HR] = 3.72, 95% confidence interval [CI] = 2.27-6.11) during the follow-up after adjustment for demographic data and medical and psychiatric comorbidities. Sensitivity analyses after excluding the observation in the first year (HR = 2.53, 95% CI = 1.44-4.47) and the first 3 years (HR = 2.14, 95% CI = 1.15-4.01) revealed consistent results. CONCLUSIONS: These results supported a temporal association between PTSD and the development of epilepsy. Further studies are warranted to investigate the underlying pathophysiological pathways that explain the longitudinal association of PTSD with subsequent epilepsy

Comorbidity · Confidence interval · Cross-sectional study · Epilepsy · Hazard ratio · Incidence (geometry) · Longitudinal study · Pathology · Posttraumatic stress · Psychiatry · Epilepsy research and treatment · Internal Medicine · Medicine · Posttraumatic Stress Disorder Research · Psychosomatic Disorders and Their Treatments

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