Effects of physical and chemical restraint on intravenous glucose tolerance test in crested black macaques ( Macaca nigra )
Bibliographic Data
| ID | 19388366 |
|---|---|
| Authors | Mitsuya Yasuda (Oregon National Primate Research Center, corresponding author), Joann Wolff (Oregon National Primate Research Center), Charles F Howard (Oregon National Primate Research Center) |
| Year | 1988 |
| Volume | 15 |
| Issue | 2 |
| Pages | 171-180 |
| Publication date | 1988-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Primatology (JOURNAL) |
| Journal identifiers | ISSN: 0275-2565 • E-ISSN: 1098-2345 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajp.1350150209 |
| PMID | 31968898 |
| OpenAlex | W2146372916 |
| Language | EN |
| References cited | 23 |
The effects of physical and chemical restraint on glucose clearance and insulin secretion were evaluated during intravenous glucose tolerance testing in Macaca nigra . Conscious monkeys placed in plexiglas cylindrical restraining devices (CRD) appeared relaxed, but glucose clearance and insulin secretion were impaired. A combination of midazolam with ketamine, compared to ketamine alone, did not cause detectable changes in the intravenous glucose tolerance tests; midazolam also reduced adverse reactions to ketamine and extended the duration of anesthesia. The cylindrical restraining device can be convenient for examining monkeys, but it is limited by its adverse affects on metabolic and hormonal measurements in intravenous glucose‐tolerance tests. Chemical restraint using ketamine with midazolam was more effective than ketamine alone
Anesthesia · Insulin · Ketamine · Midazolam · Adipose Tissue and Metabolism · Medicine · Regulation of Appetite and Obesity · Stress Responses and Cortisol · Endocrinology · Internal Medicine
| Highly cited | No |
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