Potential trade‐off between olfactory and visual discrimination learning in common marmosets ( Callithrix jacchus )
Implications for the assessment of age‐related cognitive decline
Bibliographic Data
| ID | 19388652 |
|---|---|
| Authors | Elena M Golub (0000-0002-6773-5664, Department of Psychology Smith College Northampton Massachusetts USA), Bryce Conner (Department of Psychological and Brain Sciences University of Massachusetts Amherst Massachusetts USA), Mélise Edwards (0000-0002-7453-035X, Neuroscience and Behavior Program University of Massachusetts Amherst Massachusetts USA), Lacey Gillis (Department of Psychological and Brain Sciences University of Massachusetts Amherst Massachusetts USA), Agnès Lacreuse (0000-0003-2890-9649, Department of Psychological and Brain Sciences University of Massachusetts Amherst Massachusetts USA, corresponding author) |
| Year | 2022 |
| Volume | 84 |
| Issue | 9 |
| Pages | e23427-e23427 |
| Publication date | 2022-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Primatology (JOURNAL) |
| Journal identifiers | ISSN: 0275-2565 • E-ISSN: 1098-2345 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajp.23427 |
| PMID | 35942572 |
| OpenAlex | W4292356755 |
| Language | EN |
| References cited | 56 |
Olfactory dysfunction has been identified as an early biomarker for dementia risk but has rarely been assessed in nonhuman primate models of human aging. To better characterize common marmosets as such models, we assessed olfactory discrimination performance in a sample of 10 animals (5 females), aged 2.5−8.9 years old. The monkeys were proficient in the discrimination and reversal of visual stimuli but naïve to odor stimuli. For olfactory discrimination, the monkeys performed a series of six discriminations of increasing difficulty between two odor stimuli. We found no evidence for an age‐related decline as both young and older individuals were able to perform the discriminations in roughly the same number of trials. In addition, the older monkeys had faster responses than the younger animals. However, we noted that when adjusted for age, the speed of acquisition of the first discrimination in the olfactory modality was inversely correlated to the speed of acquisition of their first discrimination of two visual stimuli months earlier. These results suggest that marmosets may compensate for sensory deficits in one modality with higher sensory performance in another. These data have broad implications for the assessment of age‐related cognitive decline and the categorization of animals as impaired or nonimpaired
Audiology · Biology · Callithrix · Categorization · Cognition · Dementia · Developmental psychology · Disease · Marmoset · Odor · Olfaction · Primate · Sensory system · Stimulus modality · Advanced Chemical Sensor Technologies · Biochemical Analysis and Sensing Techniques · Medicine · Neuroscience · Olfactory and Sensory Function Studies · Psychology · Internal Medicine
The processing-speed theory of adult age differences in cognition.
Emergence of a powerful connection between sensory and cognitive functions across the adult life span
Comparative neuropathology in aging primates
The marmoset as an important primate model for longitudinal studies of neurocognitive aging
| Highly cited | No |
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