The Interaction of Haloperidol and Imipramine on Cost-benefit Decision Making in Rats
The Interaction of Haloperidol and Imipramine on Cost-benefit Decision Making in Rats
Bibliographic Data
| ID | 19408290 |
|---|---|
| Authors | Ruisi CUI (Capital Normal University), Rui-Si CUI, Xin-Wang LI (Capital Normal University), Shuguang Wei (0000-0003-2954-344X, Capital Normal University), Shu-Guang WEI, Jingjing Jiao (0000-0003-4167-1567, Capital Normal University), Jing-Jing JIAO, Xiaolin Zhu (0000-0001-6967-786X, Capital Normal University), Xiao-Lin ZHU |
| Year | 2010 |
| Volume | 42 |
| Issue | 9 |
| Pages | 946-954 |
| Publication date | 2010-09-26 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Acta Psychologica Sinica (JOURNAL) |
| Journal identifiers | ISSN: 0439-755X |
| Publisher | China Science Publishing & Media Ltd (PUBLISHER) |
| DOI | 10.3724/sp.j.1041.2010.00946 |
| OpenAlex | W2321720034 |
| Language | EN |
| References cited | 34 |
摘要: 本实验采用T迷宫延迟奖赏模型研究多巴胺D2受体拮抗剂氟哌啶醇和5-羟色胺重摄取抑制剂丙咪嗪的交互作用对成本效益决策的影响, 同时探讨了延迟时间对决策的影响。T迷宫两臂分别设置为低成本-低奖赏端和高成本-高奖赏端。实验结果发现:氟哌啶醇能够降低大鼠选择高成本-高奖赏端的次数, 丙咪嗪则能够增加大鼠选择高成本-高奖赏端的次数; 在同时注射这两种药物情况下, 丙咪嗪能够抑制由氟哌啶醇引起的对低成本-低奖赏端的选择倾向。另外, 实验发现, 随延迟时间的增加大鼠选择高成本-高奖赏端的次数相对减少。由此可见, 丙咪嗪能够反转由氟哌啶醇导致的对低成本-低奖赏端的选择倾向, 这可能是由于细胞间5-羟色胺含量的升高部分反转了由多巴胺系统受损导致的行为倾向; 延迟时间的改变可对决策倾向产生逆转, 因此成本的支出即延迟时间也是影响成本效益决策的重要因素
Data mining · Haloperidol · Imipramine · Psychotherapist · Computer Science · Medicine · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Pharmacology and Obesity Treatment · Psychology · Receptor Mechanisms and Signaling · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |