Switch to second-line ART in West African routine care

Incidence and reasons for switching

Bibliographic Data

ID19438579
AuthorsJordi Landier (0000-0001-8619-9775, a Unité d'Epidémiologie des Maladies Emergentes , Institut Pasteur , Paris , France), Alain Akonde (b Solthis , Ségou , Mali), Cecilia Pizzocolo (c Solthis , Paris , France), Ibrahim Haidara (d Hôpital régional de Ségou , Ségou , Mali), Mahamadou Drabo (e ONG Walé , Ségou , Mali), Louis Pizarro (c Solthis , Paris , France), Arnaud Fontanet (a Unité d'Epidémiologie des Maladies Emergentes , Institut Pasteur , Paris , France), Christine Katlama (0000-0002-5093-4800, c Solthis , Paris , France), Yoann Madec (0000-0002-6201-1261, a Unité d'Epidémiologie des Maladies Emergentes , Institut Pasteur , Paris , France, corresponding author)
Year2011
Volume23
Issue1
Pages75-78
Publication date2011-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2010.498867
PMID21218279
OpenAlexW1995055229
LanguageEN
Citations received1
References cited6

In sub-Saharan Africa, while antiretroviral therapy (ART) becomes widely available, access to biological measurements to monitor patients under ART remains scarce, making the management of ART difficult. We described the management of switching to second-line ART where HIV care is provided mainly in secondary health-care structures, in the region of Segou, Mali. Of 865 patients, followed under ART for a median time of 15 months, 40 switched to second-line ART (3.3 switches/100 person years). Reason for switching was failure in 18 patients (after 21 months in median) and severe intolerance in 13 (after three months in median). Switching to second-line ART occurred earlier when motivated by intolerance than by failure. The low rate of switch compares well with other studies, but was low compared to the expected rate of failure, and may indicate that physicians are reluctant to switch ART when treatment options are limited

Antiretroviral therapy · Economic growth · Economics · Family medicine · First line · Health care · Second line · Second-line therapy · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Internal Medicine · Pediatrics · Surgery

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