Toward an information–motivation–behavioral skills model of microbicide adherence in clinical trials

Bibliographic Data

ID19439395
AuthorsRebecca A Ferrer (0000-0003-1069-9989, National Cancer Institute, corresponding author), Kathleen M Morrow (c Department of Psychiatry and Human Behavior , Warren Alpert Medical School of Brown University , Providence , RI , USA), William A Fisher (e Department of Psychology and Department of Obstetrics and Gynecology , University of Western Ontario , London , ON , Canada), Jeffrey D Fisher (0000-0001-9068-7499, University of Connecticut)
Year2010
Volume22
Issue8
Pages997-1005
Publication date2010-08-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121003623719
PMID20552466
OpenAlexW2081899659
LanguageEN
Citations received10
References cited61

Unless optimal adherence in microbicide clinical trials is ensured, an efficacious microbicide may be rejected after trial completion, or development of a promising microbicide may be stopped, because low adherence rates create the illusion of poor efficacy. We provide a framework with which to conceptualize and improve microbicide adherence in clinical trials, supported by a critical review of the empirical literature. The information-motivation-behavioral skills (IMB) model of microbicide adherence conceptualizes microbicide adherence in clinical trials and highlights factors that can be addressed in behavioral interventions to increase adherence in such trials. This model asserts that microbicide adherence-related information, motivation, and behavioral skills are fundamental determinants of adherent microbicide utilization. Specifically, information consists of objective facts about microbicide use (e.g., administration and dosage) as well as heuristics that facilitate use (e.g., microbicides must be used with all partners). Motivation to adhere consists of attitudes toward personal use of microbicides (e.g., evaluating the consequences of using microbicides as good or pleasant) as well as social norms that support their use (e.g., beliefs that a sexual partner approves use of microbicides). Behavioral skills consist of objective skills necessary for microbicide adherence (e.g., the ability to apply the microbicide correctly and consistently). Empirical evidence concerning microbicide acceptability and adherence to spermicides, medication, and condom use regimens support the utility of this model for understanding and promoting microbicide adherence in clinical trials

Clinical trial · Condom · Environmental health · Family medicine · Microbicide · Microbicides for sexually transmitted diseases · Population · Psychological intervention · Vaginal microbicide · Adolescent Sexual and Reproductive Health · HIV/AIDS Research and Interventions · Medicine · Nursing · Reproductive tract infections research · Internal Medicine