Women’s motivations for participating in the dapivirine vaginal ring open label extension study
Bibliographic Data
| ID | 19439741 |
|---|---|
| Authors | Kalendri Naidoo (0000-0002-5279-6472, University of KwaZulu-Natal, corresponding author), Elizabeth Montgomery (0000-0002-5477-4445, Women’s Global Health Imperative, RTI International, Berkeley, CA, USA), Ariana Katz (0000-0001-5742-4953, Women’s Global Health Imperative, RTI International, Berkeley, CA, USA), Morgan Garcia (0000-0002-7647-6764, Global Health Population and Nutrition, FHI 360, Durham, NC, USA), Sarita Naidoo (0000-0001-5067-1601, HIV and Other Infectious Diseases Research Unit, South African Medical Research Council, Durban, South Africa), Leila E Mansoor (0000-0002-7607-348X, University of KwaZulu-Natal) |
| Year | 2024 |
| Volume | 36 |
| Issue | 3 |
| Pages | 326-342 |
| Publication date | 2024-03-03 |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2023.2260145 |
| PMID | 37734338 |
| OpenAlex | W4386914937 |
| Language | EN |
| References cited | 25 |
Open-Label Extension (OLE) studies are important in the drug development process and are used to further support the licensing applications and regulatory approvals of products. We aimed to understand why women chose to join the HOPE OLE study – where women were offered the dapivirine vaginal ring after two pivotal trials were completed – through data collected from individual in-depth interviews. Ten women at each of the six HOPE research sites in Lilongwe, Malawi; Durban (2 sites) and Johannesburg, South Africa; Kampala, Uganda; and Chitungwiza, Zimbabwe, were enrolled (n = 60). Access to an effective user-initiated HIV prevention product was one of the main reasons women joined HOPE. Although many participants worried that their male partners might expose them to HIV, they chose to remain in their relationships and avoid conflict or confrontation with their partners by discreetly using the ring to protect themselves. Other reasons for joining were quality healthcare, reimbursement and altruism. Researchers should better understand social and personal motivators behind research participation in order to recognize community sociocultural norms and its influences on product acceptability and adherence challenges
Environmental health · Family planning · Health care · Political science · Population · Public relations · Qualitative research · Reimbursement · Sociology · Vaginal ring · Adolescent Sexual and Reproductive Health · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Psychology · Social Psychology
| Highly cited | No |
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