Development of a home-based pre-exposure prophylaxis care delivery system for long-acting injectable cabotegravir

A formative exploration of patient preferences

Bibliographic Data

ID19440264
AuthorsJanelly Gonzalez (Emory University), J M Lluna González (Emory University, corresponding author), Paulina A Rebolledo (0000-0002-9808-063X, Emory University), Aaron J Siegler (0000-0001-5553-7540, Emory University), Wenting Huang (0000-0003-0032-6986, Emory University), Kenneth H Mayer (0000-0001-7460-733X, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA), Valeria D Cantos (0000-0001-5447-3469, Division of Infectious Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA)
Year2024
Volume36
Issue12
Pages1882-1890
Publication date2024-12-01
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2024.2397128
PMID39245031
OpenAlexW4402338843
LanguageEN
Citations received1
References cited22

Cabotegravir (CAB-LA), the only Food and Drug Administration-approved injectable pre-exposure prophylaxis (PrEP), is effective and may address PrEP uptake disparities among Black and Latino sexual and gender minority (SGM) men. Uptake of CAB-LA may require developing innovative non-clinic-based care delivery strategies in home-based settings. We explored SGM men’s opinions on a future home-based CAB-LA PrEP care service to guide the adaptation of PrEP@Home, an existing home-based PrEP system for oral PrEP. Through 14 in-depth interviews with current or former SGM male participants in the PrEP@Home study, we explored the acceptability of a home-based injectable PrEP system and examined visit and communication-related preferences. All participants considered home-based CAB-LA care to be acceptable and 8/14 would utilize the system if available. Convenience and comfort with using a home-based system impacted the overall acceptance of the approach. Factors influencing acceptability included clinical teams’ affiliation with healthcare systems, a credentialed two-person team, and staff identity verification methods. Logistical preferences included communicating pre-visit patient instructions, allowing flexible scheduling hours, and the use of text, phone calls, or mobile app communication methods based on urgency. Conclusively, a home-based CAB-LA PrEP delivery system was acceptable among the interviewed SGM men, guiding its development and future implementation.Trial registration: ClinicalTrials.gov identifier: NCT03569813

Delivery system · Formative assessment · Intensive care medicine · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Pneumocystis jirovecii pneumonia detection and treatment · Psychology · Pharmacology

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