Quality of life, depression and fatigue among persons co-infected with HIV and hepatitis C

Outcomes from a population-based cohort

Bibliographic Data

ID19440591
AuthorsPaula Braitstein (0000-0003-0541-2955, University of British Columbia, corresponding author), V Montessori (AIDS Vancouver), K Chan (0009-0003-1295-2076, St. Paul's Hospital), Julio Montaner (0000-0002-6201-9829, AIDS Vancouver), J S G Montaner, Martin T Schechter (0000-0001-6063-2155, University of British Columbia), Michael V O’shaughnessy (0000-0003-1402-935X, AIDS Vancouver), Robert S Hogg (0000-0003-3463-5488, St. Paul's Hospital)
Year2005
Volume17
Issue4
Pages505-515
Publication date2005-05-01
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540120412331291733
PMID16036236
OpenAlexW2024489750
LanguageEN
Citations received14
References cited42

The objective of the study was to describe the additional burden generated by hepatitis C (HCV) infection among HIV-infected individuals as measured by self-reported quality of life, depression and fatigue. The provincial HIV/AIDS Drug Treatment Program (DTP) distributes all antiretroviral medication in the province of British Columbia. Eligibility for accessing antiretrovirals is based on published guidelines commensurate with the International AIDS Society. Each participant is asked to complete a self-administered mailed questionnaire that includes patient sociodemographic information, quality of life measures (Medical Outcomes Study-Short Form (MOS-SF), mental health issues (Centre for Epidemiological Studies Depression scale (CESD) and fatigue information. HIV-HCV co-infected individuals were compared to HIV mono-infected individuals using parametric and nonparametric methods. Multivariate logistic regression was used to examine the impact of hepatitis C on quality of life, depression and fatigue, after controlling for sociodemographics and HIV-specific clinical characteristics. Of the 4,134 individuals who were sent a HIV/AIDS DTP survey in 1999, 2000 or 2001, 484 participants both returned one and had an HCV-antibody test result on file. Of the 484 participants eligible for this analysis, 105 (22%) were HCV-positive. In comparison to the 379 (78%) patients testing negative for HCV, a larger proportion of co-infected patients were female (18% versus 3%, p<0.001), aboriginal (20% versus 3%, p<0.001), had ever injected drugs (79% versus 5%, p<0.001), were unemployed (91% versus 49%, p<0.001) and lived in unstable housing (19% versus 1%, p<0.001) at the time they completed the survey. Co-infected patients reported more symptoms consistent with depression, increased fatigue and poorer quality of life. However, using multivariate modeling, it was determined that the impact of HCV on quality of life, depression and fatigue was better explained by the sociodemographic factors related to poverty and injection drug use, than by HCV itself. In conclusion, individuals co-infected with HIV and HCV represent a patient population with significant physical and mental health challenges. Although these patients experience poorer quality of life, increased depression and fatigue, this experience appears to be primarily related to socio-economic issues rather than HCV infection

Cohort · Cohort study · Environmental health · Hepatitis C · Logistic regression · Mental health · Population · Psychiatry · Hepatitis C virus research · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Epidemiology · Internal Medicine

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