High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana

Dados Bibliográficos

ID19441046
AutoresJustin S Nichols (Yale University), Tassos C Kyriakides (0000-0001-8913-108X), Sampson Antwi (0000-0003-0957-6105, Kwame Nkrumah University of Science and Technology), Lorna Renner (0000-0001-7902-773X, University of Ghana), Margaret Lartey (University of Ghana), Obedia A Seaneke (Korle Bu Teaching Hospital), Raphael Obeng (Kwame Nkrumah University of Science and Technology), Ann Christine Catlin (0000-0001-8314-1623, Purdue University West Lafayette), Geliang Gan (0000-0001-6984-754X), Nancy R Reynolds, Nancy Reynolds (0000-0002-5023-1953, Johns Hopkins University), Elijah Paintsil (0000-0002-8283-4564, Yale University, autor correspondente), on Behalf of the Sankofa Study Team
Ano2019
Volume31
Fascículo1
Páginas25-34
Data de publicação2019-01-02
Peer ReviewedSim
Open AccessNão
TipoARTICLE
PeriódicoAIDS Care (JOURNAL)
Identificadores do periódicoISSN: 0954-0121 • E-ISSN: 1360-0451
EditoraInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2018.1524113
PMID30235940
OpenAlexW2891315683
IdiomaEN
Citações recebidas4
Referências citadas28

Adherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought to determine the prevalence of adherence to ART among undisclosed HIV-infected children and adolescents in Ghana. We analyzed baseline data from HIV-infected children and adolescents aged 7-18 years old enrolled in the SANKOFA Pediatric HIV disclosure intervention study in Ghana. Antiretroviral medication adherence was measured using caregiver 3-day recall; child 3-day recall; and pharmacy records for antiretroviral time-to-refill. Four hundred and twenty child-caregiver dyads were enrolled from January 2013 to June 2016. The median adherence (interquartile range), as measured by time-to-refill, was 93.2% (68.0%-100.0%). However, only 47.5% of children had ≥95% adherence ("good adherence") using time-to-refill data. Children of caregivers who had received secondary or higher level of education versus no school (aOR, 2.90, 95% Confidence Interval, CI 1.29-6.56), p = 0.010) or elementary education only (aOR, 2.20, CI, 1.24-3.88, p = 0.007) were more likely to have "good adherence" (≥95%). In this cohort of children unaware of their HIV positive status, median ART adherence rate was sub-optimal (by World Health Organization definition) while 38% had poor adherence (<85%)

Antiretroviral therapy · Cohort · Confidence interval · Family medicine · Interquartile range · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Internal Medicine · Pediatrics