Prevention of HIV transmission with sperm washing within fertile serodiscordant couples undergoing non-stimulated intrauterine insemination
Bibliographic Data
| ID | 19441086 |
|---|---|
| Authors | Waldemar de Almeida Pereira de Carvalho (0000-0003-0164-2198, Ideia Fértil, Santo André, Brazil, corresponding author), Edir Catafesta (Ideia Fértil, Santo André, Brazil), Itatiana Ferreira Rodart (0000-0001-8370-9303, Ideia Fértil, Santo André, Brazil), Silvio Takata (Ideia Fértil, Santo André, Brazil), Denise Lotufo Estevam, Caio Parente Barbosa (0000-0002-2922-0264, Ideia Fértil, Santo André, Brazil) |
| Year | 2021 |
| Volume | 33 |
| Issue | 4 |
| Pages | 478-485 |
| Publication date | 2021-04-03 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2020.1739201 |
| PMID | 32178530 |
| OpenAlex | W3012316982 |
| Language | EN |
| Citations received | 1 |
| References cited | 23 |
The purpose of this prospective non-randomized study was to study the effectiveness of semen washing followed by intrauterine insemination (IUI) in Human Immune Deficiency Virus (HIV)-discordant couples in which the male partner was infected, in preventing HIV transmission to uninfected partner and offspring. The study was performed in a private assisted reproductive center specialized in couples with infectious diseases and enrolled sixty-nine fertile couples in which male partner tested positive for HIV, seeking for reproductive treatment. Triple sperm washing followed by viral RNA purification and real-time polymerase chain reaction was performed prior to IUI intervention. HIV transmission to female partner and newborns, and clinical pregnancy rate were the main outcome measures. A total of 180 IUI treatment cycles were performed in 69 couples. There were 16 clinical pregnancies (clinical pregnancy rate/cycle 9.0%, clinical pregnancy rate/patient 23.2%), one of which resulted in miscarriage (6.3%). No seroconversion was detected in the 69 women treated with sperm washing followed by IUI or in any of the newborns (tested at birth and at 3 months of age). Sperm washing followed by IUI is a safe and effective treatment option for serodiscordant couples wishing to conceive and to prevent HIV virus transmission to the mothers and newborns
Andrology · Artificial insemination · Biology · Gynecology · Infertility · Insemination · Live birth · Miscarriage · Obstetrics · Pregnancy · Pregnancy rate · Semen · Seroconversion · Serodiscordant · Sperm · Sperm washing · Viral load · Adolescent Sexual and Reproductive Health · HIV/AIDS Research and Interventions · Medicine · Sex work and related issues · Immunology
Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women
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Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD)
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |