Single tablet HIV regimens facilitate virologic suppression and retention in care among treatment naïve patients
Bibliographic Data
| ID | 19441964 |
|---|---|
| Authors | Vagish Hemmige (0009-0006-6346-1826, Baylor College of Medicine), Charlene Flash (0000-0002-3280-2134, Baylor College of Medicine), Josephinel Carter (Texas Southern University School of Health Sciences, Houston, TX, USA), Thomas P Giordano (0000-0002-9346-5530, Baylor College of Medicine, corresponding author), Teddy Zerai (Harris Health System, Houston, TX, USA) |
| Year | 2018 |
| Volume | 30 |
| Issue | 8 |
| Pages | 1017-1024 |
| Publication date | 2018-08-03 |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2018.1442554 |
| PMID | 29478329 |
| OpenAlex | W2791116077 |
| Language | EN |
| Citations received | 1 |
| References cited | 28 |
Newer HIV regimens are typically taken once daily but vary in the number of pills required. Whether the number of pills in a once-daily HIV regimen affects clinical outcomes is unknown. We retrospectively compared adherence, retention in care, and virologic outcomes between patients starting a once daily single-tablet regimen (STR) to patients starting a once-daily multi-tablet regimen (MTR) in a publicly funded clinic in the United States. Outcomes were measured in the year after starting ART and included retention in care, virologic suppression, and medication possession ratio of at least 80%. Data from patients initiating therapy from 1 January 2008 to 31 December 2011 were analyzed with both unadjusted and propensity-score adjusted regression. Overall, 622 patients started with an STR (100% efavirenz-based) and 406 with an MTR (65% atazanavir-based and 35% darunavir-based) regimen. Retention in care was achieved in 80.7% of STR patients vs. 72.7% of MTR patients (unadjusted OR 1.57, 95% CI 1.17-2.11; adjusted OR 1.49, 95% CI 1.10-2.02). Virologic suppression occurred among 84.4% of STR patients vs. 77.6% of MTR patients (unadjusted OR 1.56; 95% CI 1.14-2.15; adjusted OR 1.41; 95% CI 1.02-1.96). There was no difference in the proportion of patients achieving at least 80% adherence, as measured by medication possession ratio (33.0% of STR patients and 30.1% of MTR patients; unadjusted OR 1.14; 95% CI 0.87-1.50; adjusted OR 1.04, CI 0.79-1.38). While it is difficult to eliminate confounding in this observational study, retention in care and virologic outcomes were better in patients prescribed STRs
Antiretroviral therapy · Atazanavir · Darunavir · Efavirenz · Pill · Propensity score matching · Regimen · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Immunology · Internal Medicine
Applied Logistic Regression
The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection
Retention in Care
Guidelines for Improving Entry Into and Retention in Care and Antiretroviral Adherence for Persons With HIV
The central role of the propensity score in observational studies for causal effects
An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies
Comparing Adherence to Two Different HIV Antiretroviral Regimens
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |