Adherence to antiretroviral therapy and factors associated with non-adherence
A cohort study at two referral services in Brazil
Bibliographic Data
| ID | 19442197 |
|---|---|
| Authors | Rosário Antunes Fonseca Lima (0000-0002-9110-8329, Universidade de Pernambuco, corresponding author), Demócrito De Barros Miranda Filho (0000-0003-2537-1476, Universidade de Pernambuco), Ulisses Ramos Montarroyos (0000-0001-8967-5693, Universidade de Pernambuco), Aracele Tenório de Almeida e Cavalcanti (0000-0001-8134-5438, Universidade de Pernambuco), Ricardo Arraes De Alencar Ximenes (0000-0002-9951-8840, Universidade de Pernambuco) |
| Year | 2023 |
| Volume | 35 |
| Issue | 7 |
| Pages | 961-969 |
| Publication date | 2023-07-03 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2022.2029814 |
| PMID | 35100884 |
| OpenAlex | W4210310450 |
| Language | EN |
| Citations received | 1 |
| References cited | 24 |
This cohort study evaluated non-adherence to antiretrovirals at referral services in Pernambuco, Brazil, 2016/2017, through self-report. A generalized mixed-effects model for binary outcomewas used. We assessed 542 participants with an adherence rate of 85.50%. A greater chance of non-adherence was associated with:a low/moderate level of nicotine dependence (OR = 2.79, p = 0.00, IC = 1.44-5.41); ≥7 tablets/day (OR = 6.14, p = 0.00, IC = 3.42-11.02); LPV/r (OR = 1.49, p = 0.6, IC = 0.98-2.26), ddI (OR = 3.34, p = 0.03, IC = 1.12-9.97), ABC (OR = 4.02, p = 0.05, IC = 1.01-16.03), RAL (OR = 2.49, p = 0.01, IC = 1.32-4.70) and DTG (OR = 4.65, p = 0.01, IC = 1.42-15.16); 6–10 year seropositive diagnosis (OR = 2.17, p = 0.01, IC = 1.20-3.92) and symptoms of depression (OR = 1.55, p = 0.03, IC = 1.03-2.33). Protective factors for non-adherence weres: ≥50 years (OR = 0.67, p = 0.06, IC = 0.45-1.01), secondary/higher education (OR = 0.48, p = 0.00, IC = 0.34-0.70), embarrassment at health service (OR = 0.49, p = 0.04, IC = 0.24-0.97), good understanding of antiretrovirals (OR = 0.62, p = 0.03, IC = 0.40-0.96), adverse event (OR = 0.74, p = 0,06, IC = 0.54-1.01), use of TDF (OR = 0.62, p = 0.01, IC = 0.43-0.90), NVP (OR = 0.41, p = 0.05, IC = 0.71-1.00) and EFZ (OR = 0.48, p = 0.01, IC = 0.29-0.80) and good knowledge of HIV/AIDS/ART. (OR = 0.67, p = 0.07, IC = 0.43-1.04). Variables with stronger association were those linked to ART. Systematic use of self-report adherence is recommended for priority groups
Adverse effect · Cohort · Family medicine · Referral · HIV/AIDS Research and Interventions · Medication Adherence and Compliance · Medicine · Syphilis Diagnosis and Treatment · Internal Medicine
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |