Newly diagnosed HIV positive children

A unique index case to improve HIV diagnosis and linkage to care of parents

Bibliographic Data

ID19442217
AuthorsJillian Neary (0000-0003-1166-0760, Departments of Global Health, University of Washington, Seattle, WA, USA, corresponding author), Irene Njuguna (0000-0003-4250-3231, Kenyatta National Hospital), Irene N Njuguna (Departments of Epidemiology, University of Washington, Seattle, WA, USA), Lisa M Cranmer (0000-0002-6938-9195, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, USA), Vincent O Otieno (Kenya Medical Research Institute, Kisumu, Kenya), Vincent Otieno (0000-0001-9805-3394, Kenya Medical Research Institute), Cyrus Mugo (0000-0001-7516-2168, Departments of Global Health, University of Washington, Seattle, WA, USA), Hellen M Okinyi (University of Nairobi), Sarah Benki‐Nugent (0000-0002-3034-8257, University of Washington), Sarah Benki-Nugent (0000-0002-3564-6245, Departments of Global Health, University of Washington, Seattle, WA, USA), Barbra A Richardson (0000-0001-9564-1828, Departments of Global Health, University of Washington, Seattle, WA, USA), Joshua Stern (0000-0002-5424-9421, Departments of Biostatistics, University of Washington, Seattle, WA, USA), Elizabeth Maleche-Obimbo (University of Nairobi), Elizabeth Maleche‐Obimbo (0000-0001-7871-3367, University of Nairobi), Dalton Wamalwa (0000-0002-5510-462X, University of Nairobi), Dalton C Wamalwa (University of Nairobi), Grace John‐Stewart (0000-0002-4301-1573, University of Washington), Grace C John-Stewart (Departments of Global Health, University of Washington, Seattle, WA, USA), Anjuli D Wagner (0000-0002-5851-1220, Departments of Global Health, University of Washington, Seattle, WA, USA)
Year2020
Volume32
Issue11
Pages1400-1405
Publication date2020-11-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2020.1719027
PMID32019333
OpenAlexW3004886496
LanguageEN
Citations received1
References cited25

Newly diagnosed HIV positive children may be unique index cases to identify undiagnosed parents. Data was used from the Pediatric Urgent Start of HAART (NCT02063880) trial, which enrolled hospitalized, ART-naïve, HIV positive children ages 0–12 years in Kenya. Exact McNemar’s tests were used to compare proportions of mothers and fathers tested for HIV, linked to care, and on ART at baseline and 6 months. This analysis included 87 newly diagnosed children with HIV who completed 6 months of follow-up. Among 83 children with living mothers, there were improvements in maternal linkage to care and treatment comparing baseline to 6 months (36% vs. 78%; p < 0.0001 and 22% vs. 52%; p < 0.0001). Among 80 children with living fathers, there were increases from baseline to 6 months in the number of fathers who knew the child’s HIV status (34% vs. 78%; p < 0.0001), fathers ever tested for HIV (43% vs. 65%; p < 0.0001), fathers ever tested HIV positive (21% vs. 43%; p < 0.0001), fathers ever linked to care (15% vs. 35%; p < 0.0001), and fathers ever initiated on ART (11% vs. 23%; p = 0.0039). Newly diagnosed HIV positive children can be important index cases to identify parents with undiagnosed HIV or poor engagement in care

Antiretroviral therapy · Family medicine · HIV diagnosis · McNemar's test · Viral load · Adolescent Sexual and Reproductive Health · Demography · HIV Research and Treatment · HIV/AIDS Research and Interventions · Medicine · Pediatrics