Impact of adherence counseling dose on antiretroviral adherence and HIV viral load among HIV-infected methadone maintained drug users

Bibliographic Data

ID19442341
AuthorsNina A Cooperman (0000-0002-2086-6042, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, corresponding author), Moonseong Heo (0000-0001-7711-1209, Albert Einstein College of Medicine and Montefiore Medical Center), Karina M Berg (0000-0001-7536-3760, Albert Einstein College of Medicine and Montefiore Medical Center), Xuan Li (0000-0003-0366-872X, Albert Einstein College of Medicine and Montefiore Medical Center), Alain H Litwin (0000-0002-6717-0288, Albert Einstein College of Medicine and Montefiore Medical Center), Shadi Nahvi (0000-0001-5501-4942, Albert Einstein College of Medicine and Montefiore Medical Center), Julia H Arnsten (0000-0002-7741-1567, Albert Einstein College of Medicine and Montefiore Medical Center)
Year2012
Volume24
Issue7
Pages828-835
Publication date2012-07-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2011.644231
PMID22272732
PMCIDPMC3380183
OpenAlexW2026757358
LanguageEN
Citations received2
References cited25

Adherence counseling can improve antiretroviral adherence and related health outcomes in HIV-infected individuals. However, little is known about how much counseling is necessary to achieve clinically significant effects. We investigated antiretroviral adherence and HIV viral load relative to the number of hours of adherence counseling received by 60 HIV-infected drug users participating in a trial of directly observed antiretroviral therapy delivered in methadone clinics. Our adherence counseling intervention combined motivational interviewing and cognitive-behavioral counseling, was designed to include six 30 minute individual counseling sessions with unlimited "booster" sessions, and was offered to all participants in the parent trial. We found that, among those who participated in adherence counseling, dose of counseling had a significant positive relationship with antiretroviral adherence measured after the conclusion of counseling. Specifically, a liner mixed-effects model revealed that each additional hour of counseling was significantly associated with a 20% increase in post-counseling adherence. However, the number of cumulative adherence counseling hours was not significantly associated with HIV viral load, also measured after the conclusion of counseling. Our findings suggest that more intensive adherence counseling interventions may have a greater impact on antiretroviral adherence than less intensive interventions; however, it remains unknown how much counseling is required to impact HIV viral load

Antiretroviral therapy · Drug · Methadone · Methadone maintenance · Psychiatry · Viral load · HIV, Drug Use, Sexual Risk · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Virology

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