Acceptability of the dapivirine vaginal ring for HIV-1 prevention among women reporting engagement in transactional sex

Bibliographic Data

ID19443231
AuthorsErica N Browne (0000-0003-2069-6589, Women’s Global Health Imperative, RTI International, Berkeley, CA, USA, corresponding author), Kristine Torjesen (0000-0002-3439-1199, FHI 360, Durham, NC, USA), Brenda Gati Mirembe (0000-0001-9074-6751, Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda), Thesla Palanee‐phillip (0000-0002-0052-5830, University of the Witwatersrand), Thesla Palanee-Phillips (University of the Witwatersrand), Nitesha Jeenarain (South African Medical Research Council, Durban, South Africa), Miria Chitukuta (0000-0002-7345-0251, University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe), Marie C D Stoner (0000-0002-7189-8669, Women’s Global Health Imperative, RTI International, Berkeley, CA, USA), Leila E Mansoor (0000-0002-7607-348X, University of KwaZulu-Natal), Krishnaveni Reddy (0000-0002-3881-2704, University of the Witwatersrand), Thelma Tauya (University of Zimbabwe), Thelma T Tauya (University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe), Logashvari Naidoo (0000-0003-3766-7370, South African Medical Research Council, Durban, South Africa), Samantha Siva (South African Medical Research Council, Durban, South Africa), Barbra Richardson (University of Washington), Barbra A Richardson (0000-0001-9564-1828, University of Washington), Sufia Dadabhai (0000-0002-4965-1440, College of Medicine-John Hopkins University Research Project, Blantyre, Malawi), Linly Seyama (0009-0002-1494-7679, College of Medicine-John Hopkins University Research Project, Blantyre, Malawi), Lydia Soto-Torres (Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Mental Health, and Eunice Shriver Kennedy, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA), Lydia Soto‐Torres (National Institutes of Health), Ariane Van Der Straten (0000-0001-8536-648X, University of California, San Francisco), On behalf of the MTN-020/ASPIRE Study Team
Year2024
Volume36
Issue1
Pages80-86
Publication date2024-01-02
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2023.2198187
PMID37066990
OpenAlexW4366084209
LanguageEN
Citations received1
References cited14

We assessed if acceptability of the dapivirine vaginal ring for HIV prevention differed among the subgroup of women who reported engaging in transactional sex prior to enrollment in MTN-020/ASPIRE (phase III trial in Malawi, South Africa, Uganda, and Zimbabwe, 2012-2015; n = 2629). Transactional sex was defined as receipt of money, goods, gifts, drugs, or shelter in exchange for sex in the past year. Dimensions of acceptability included: ease of use and physical sensation in situ, impacts on sex, partner’s opinion, and likelihood of future use. We used Poisson regression models with robust standard errors to compare risk of acceptability challenges by baseline history of transactional sex. At product discontinuation, women exchanging sex found the ring comfortable (90%), easy to insert (92%) and nearly all (96%) were likely to use the ring in the future. Women who had exchanged sex were more likely to report feeling the ring during sex (ARR 1.43, 95% CI: 1.09, 1.89; p = 0.01) and slightly more likely to mind wearing the ring during menses (ARR 1.22, 95% CI: 1.01, 1,46; p = 0.04) and during sex (ARR 1.22, 95% CI: 1.02, 1.45; p = 0.03). Messaging and counseling should include enhanced support for use during sex and menses to support optimal use

Discontinuation · Environmental health · Family medicine · Family planning · Feeling · Female sex · Gynecology · Men who have sex with men · Poisson regression · Population · Psychiatry · Transactional sex · Vaginal ring · Adolescent Sexual and Reproductive Health · Demography · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Psychology · Social Psychology · Internal Medicine