Retrospective analysis of factors influencing immunologic failure among people living with HIV on antiretroviral therapy

Bibliographic Data

ID19443436
AuthorsDonglan Chen (Guangdong Medical University Affiliated Hospital, corresponding author), Qiuhua Chen (0000-0002-5481-6633, Guangdong Medical University Affiliated Hospital), Manzhou Lin (Guangdong Medical University Affiliated Hospital)
Year2025
Volume37
Issue9
Pages1475-1481
Publication date2025-09-02
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2025.2534541
PMID40719512
OpenAlexW4412696685
LanguageEN
References cited23

A retrospective analysis was performed on 98 people living with HIV-1 (PLHIV) undergoing antiretroviral therapy (ART) between July 2019 and July 2023. The incidence of poor CD4+ T cell recovery was 27.55% (27/98), while the immunologic reconstruction success rate was 72.45% (71/98). Multivariate logistic regression analysis confirmed 5 independent high-risk factors for treatment failure: age ≥ 60 years (β = 1.473, OR = 4.364, 95% CI = 1.614–11.799, P = 0.004), injection drug use (β = 1.792, OR = 6.000, 95% CI = 1.030–34.936, P = 0.046), co-infection (β = 1.530, OR = 4.620, 95% CI = 1.321–16.157, P = 0.017), time from diagnosis-to-treatment initiation ≥ 12 months (β = 1.348, OR = 3.850, 95% CI = 1.236–11.992, P = 0.020), and baseline CD4+ T cells count < 200 /μL (β = 2.071, OR = 7.934, 95% CI = 2.915–21.594, P = 0.000)

Antiretroviral therapy · Environmental health · Intensive care medicine · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Immunology · Virology

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