Amphetamine use and its associations with antiretroviral adherence and viral load among sexual minority men and transgender women living with HIV
Bibliographic Data
| ID | 19443577 |
|---|---|
| Authors | Natalie M Brousseau (0000-0003-4450-8888, Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA, corresponding author), Seth C Kalichman (0000-0002-0912-5112, Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA), R J Watson (0000-0001-7824-7714, Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA), Lisa A Eaton (Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA) |
| Year | 2023 |
| Volume | 35 |
| Issue | 10 |
| Pages | 1472-1479 |
| Publication date | 2023-10-03 |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2023.2206096 |
| PMID | 37139536 |
| OpenAlex | W4368355621 |
| Language | EN |
| Citations received | 3 |
| References cited | 19 |
Substance use has complex associations to HIV disease progression. The current study tested the associations between several substances and HIV viral load while accounting for confounders relevant to HIV disease progression and substance use. Young sexual minority men and transgender women living with HIV (LWH) in Georgia (N = 385) completed measures and biological tests for HIV viral load and substance use. Multivariable regression models tested the role of specific drugs (i.e., alcohol, cannabis/THC, cocaine, and combined amphetamine and methamphetamine) directly on viral load and indirectly through antiretroviral (ART) adherence. ART adherence and HIV care self-efficacy were consistently associated with greater HIV suppression. Alcohol and cocaine were not associated with ART adherence or viral load. Cannabis was negatively associated with ART adherence (B = −.053, p = .037) but not viral load. Amphetamine/methamphetamine demonstrated significant direct effects on higher viral load (B = .708, p = .010) while indirectly influencing viral load through a negative association with ART adherence. Our findings support previous research demonstrating amphetamine/methamphetamine use impacts viral load both directly and indirectly through ART adherence. Interventions addressing amphetamine/methamphetamine use by young sexual minority men and transgender women LWH are urgently needed, and future research should focus on determining the mechanisms by which formulations of amphetamine impact HIV replication.Trial registration: ClinicalTrials.gov identifier: NCT03665532
Amphetamine · Cannabis · Men who have sex with men · Methamphetamine · Psychiatry · Psychological intervention · Syphilis · Transgender · Viral load · Clinical Psychology · HIV Research and Treatment · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Psychology · Immunology · Internal Medicine
For Whom Does Chemsex Increase Sexual Risk? Considering Pre-Exposure Prophylaxis (PrEP), Antiretroviral Therapy (ART), and the Dual Control Model
Understanding African American/Black and Latine young and emerging adults living with HIV
Acceptability and Feasibility of Self-Collected Dried Blood Spot Specimens for Viral Load Monitoring among Rural Older People Living with HIV
| Citations per year | 3 |
|---|---|
| Citation span | 2025 - 2026 (2) |
| Highly cited | No |