Improvements in depression and changes in quality of life among HIV-infected adults

Bibliographic Data

ID19444115
AuthorsAngela M Bengtson (0000-0003-1305-8132, Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, corresponding author), Brian W Pence (0000-0001-7321-9538, Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA), Julie O’donnell (0000-0002-3617-5836, University of North Carolina at Chapel Hill), Nathan Thielman (Duke University), Nathan M Thielman (0000-0001-8152-2879, Duke University), Amy Heine (Department of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA), Anne Zinski (0000-0003-0414-248X, University of Alabama at Birmingham), Riddhi Modi (0000-0002-0047-1035, University of Alabama at Birmingham), Teena M McGuinness (0000-0003-1208-1007, University of Alabama at Birmingham), Teena McGuinness (University of Alabama at Birmingham), Bradley N Gaynes (0000-0002-8283-5030, University of North Carolina at Chapel Hill), Bradley Gaynes (Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)
Year2015
Volume27
Issue1
Pages47-53
Publication date2015-01-02
Open AccessNo
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2014.946386
PMID25105320
PMCIDPMC4402235
OpenAlexW1965604285
LanguageEN
Citations received15
References cited32

Improving quality of life (QOL) for HIV-infected individuals is an important objective of HIV care, given the considerable physical and emotional burden associated with living with HIV. Although worse QOL has been associated with depression, no research has quantified the potential of improvement in depression to prospectively improve QOL among HIV-infected adults. We analyzed data from 115 HIV-infected adults with depression enrolled in a randomized controlled trial to evaluate the effectiveness of improved depression care on antiretroviral drug adherence. Improvement in depression, the exposure of interest, was defined as the relative change in depression at six months compared to baseline and categorized as full response (≥50% improvement), partial response (25-49% improvement), and no response (<25% improvement). Multivariable linear regression was used to investigate the relationship between improvement in depression and four continuous measures of QOL at six months: physical QOL, mental QOL, HIV symptoms, and fatigue intensity. In multivariable analyses, physical QOL was higher among partial responders (mean difference [MD] = 2.51, 95% CI: -1.51, 6.54) and full responders (MD = 3.68, 95% CI: -0.36, 7.72) compared to individuals who did not respond. Mental QOL was an average of 4.01 points higher (95% CI: -1.01, 9.03) among partial responders and 14.34 points higher (95% CI: 9.42, 19.25) among full responders. HIV symptoms were lower for partial responders (MD = -0.69; 95% CI: -1.69, 0.30) and full responders (MD = -1.51; 95% CI: -2.50, -0.53). Fatigue intensity was also lower for partial responders (MD = -0.94; 95% CI: -1.94, 0.07) and full responders (MD = -3.00; 95% CI: -3.98, -2.02). Among HIV-infected adults with depression, improving access to high-quality depression treatment may also improve important QOL outcomes

Mental health · Physical therapy · Psychiatry · Randomized controlled trial · Family Caregiving in Mental Illness · HIV-related health complications and treatments · HIV/AIDS Research and Interventions · Medicine · Immunology · Internal Medicine

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