Impact of first-line antiretroviral therapy choice on adverse drug reactions in children with HIV infection
A retrospective cohort study in southwest China
Bibliographic Data
Antiretroviral therapy (ART) is essential in managing children with human immunodeficiency virus (HIV) infection, but is often complicated by adverse drug reactions (ADRs), which can significantly impact therapeutic outcomes. This study investigates ADRs in 375 children with HIV receiving zidovudine (AZT)- or abacavir (ABC)-based ART regimens, using Kaplan-Meier, Cox regression analyses to evaluate ADR incidences, and propensity score matching (PSM) to address confounders. We found ADRs occurred in 21.9% of the cohort. Incidence was significantly higher with the ABC-based regimen (31.2%) versus the AZT-based regimen (17.2%). Most ADRs—primarily gastrointestinal—emerged within the first month of ART. Cox regression analysis confirmed ABC-based regimen nearly tripled the ADR risk (adjusted hazard ratio [aHR] = 2.987, P < 0.001). Notably, children at advanced WHO clinical stages (III-IV) on the ABC-based regimen faced even greater risk (aHR = 3.190, P = 0.005) compared to earlier stages (I-II). These results underscore the need for regimen customization based on disease severity to improve safety and efficacy in pediatric HIV treatment, informing optimized ART protocols and personalized strategies
Abacavir · Adverse effect · Antiretroviral therapy · Atazanavir · Cohort · Cohort study · Confidence interval · Hazard ratio · Propensity score matching · Proportional hazards model · Regimen · Retrospective cohort study · Viral disease · Viral load · Zidovudine · HIV Research and Treatment · HIV/AIDS drug development and treatment · Medicine · Pneumocystis jirovecii pneumonia detection and treatment · Immunology · Internal Medicine · Pediatrics
Associations Between Childhood Sexual Abuse, Intimate Partner Violence Trauma Exposure, Mental Health, and Social Gender Affirmation Among Black Transgender Women
Nevirapine-related adverse events among children switched from efavirenz to nevirapine as compared to children who were started on nevirapine-based antiretroviral therapy directly
Experiences of stigma and HIV care engagement in the context of Treat All in Rwanda
Impact of Community Support Workers in Rural Ethiopia on Emotional and Psychosocial Health of Persons Living with HIV
Application of the Consolidated Framework for Implementation Research to Facilitate Delivery of Trauma-Informed HIV Care
| Citation velocity | historical |
|---|---|
| Highly cited | No |