Association of CD4+ T cell subpopulations and psychological stress measures in women living with HIV
Bibliographic Data
| ID | 19444297 |
|---|---|
| Authors | Kristina E Rehm (Laboratory of Behavioral Immunology, Division of Clinical Immunology and Allergy, University of Mississippi Medical Center, Jackson, MS, USA, corresponding author), Deborah J Konkle-Parker (0000-0002-3319-8442, University of Mississippi Medical Center), Deborah Konkle-Parker (Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA) |
| Year | 2017 |
| Volume | 29 |
| Issue | 9 |
| Pages | 1107-1111 |
| Publication date | 2017-09-02 |
| Open Access | No |
| Type | ARTICLE |
| Venue | AIDS Care (JOURNAL) |
| Journal identifiers | ISSN: 0954-0121 • E-ISSN: 1360-0451 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/09540121.2017.1281880 |
| PMID | 28114801 |
| OpenAlex | W2582739682 |
| Language | EN |
| References cited | 19 |
Psychological stress is a known immunomodulator. In individuals with HIV, depression, the most common manifestation of increased psychological stress, can affect immune function with lower CD4+ T cell counts correlating with higher levels of depression. It is unknown how other forms of psychological stress can impact immune markers in people living with HIV. We conducted a cross-sectional study to determine how CD4+ T cell subpopulations correlated with different forms of psychological stress. We recruited 50 HIV-positive women as part of the Women’s Interagency HIV Study. We assessed perceived stress, worry, acute anxiety, trait anxiety, and depression through self-report questionnaires and CD4+ T cell subpopulations using flow cytometry. Our sample was 96% African-American with a mean ± SD age and body mass index of 42 ± 8.8 years and 36.6 ± 11.5 kg/m2, respectively. The mean ± SD scores on the psychological measures were as follows: Perceived Stress Scale (PSS), 16.5 ± 6.4; Penn State Worry Questionnaire (PSWQ), 47.7 ± 13.8; State-Trait Anxiety Inventory – State (STAIS), 39.1 ± 12.3; State-Trait Anxiety Inventory – Trait (STAIT), 40.2 ± 11.4; Center for Epidemiological Studies Depression Scale (CES-D), 15.6 ± 11.4. The mean + SD values for the immune parameters were as follows: regulatory T cells (Treg), 1.25% ± 0.7; T helper 1 (Th1), 14.9% ± 6.1; T helper 2 (Th2), 3.8% ± 2; Th1/Th2 ratio, 4.6 ± 3; and CD4+ T cell count (cells/mm3), 493 ± 251. Treg levels positively correlated with PSS, STAIS, and STAIT. CD4+ T cell count negatively correlated with PSS, PSWQ, STAIS, STAIT, and CES-D. These data suggest that immune function may be impacted by various forms of psychological stress in HIV-positive women. Interventions that target stress reduction may be useful in improving immune parameters and quality of life
Psychological stress · Psychotherapist · Clinical Psychology · Health, psychology, and well-being · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Immunology
Experience of persistent psychological symptoms and perceived stigma among people with HIV on antiretroviral therapy (ART)
Development and validation of the penn state worry questionnaire
Measures of anxiety
Measures of depression and depressive symptoms
Depression and CD4 Cell Count Among Persons with HIV Infection in Uganda
A Global Measure of Perceived Stress
| Highly cited | No |
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