Diversity and relationship between Iranian ethnic groups

Human dopamine transporter gene ( DAT1 ) VNTR genotyping

Bibliographic Data

ID19459137
AuthorsMohammad Mehdi Banoei (0000-0002-1841-7408, National Institute of Genetic Engineering and Biotechnology, corresponding author), Morteza Hashemzadeh Chaleshtori (0000-0002-8700-5554, National Institute of Genetic Engineering and Biotechnology, corresponding author), Mohammad Hossein Sanati (0000-0002-0292-7673, National Institute of Genetic Engineering and Biotechnology), Mohammah Hossein Sanati, Mehdi Shafa Sharait Panahi (National Institute of Genetic Engineering and Biotechnology), Tayebeh Majidizadeh (0000-0001-7500-0185, National Institute of Genetic Engineering and Biotechnology), Maryam Rostami (0000-0002-4388-6345, National Institute of Genetic Engineering and Biotechnology), Massoumeh Dehghan Manshadi (National Institute of Genetic Engineering and Biotechnology), Masoud Golalipour (0000-0002-3429-5519, National Institute of Genetic Engineering and Biotechnology)
Year2007
Volume19
Issue6
Pages821-826
Publication date2007-11-01
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.20647
PMID17712789
OpenAlexW2090809413
LanguageEN
Citations received2
References cited13

The 40‐bp VNTR polymorphism in the 3′ untranslated region of the human DAT1 (dopamine transporter 1) was analyzed in the Iranian ethnic groups in order to examine the influence of geographical and linguistic affiliation on the genetic affinities among the Iranian population. A total of 449 subjects belonging to nine ethnic groups from the Iranian population were included in the study. The screening of 898 chromosomes showed five alleles (6, 7, 8, 9, 10, and 11), of which allele 10 revealed the highest frequency in most regions. Allele 8 was predominant in one ethnicity and occurred more frequently in the center of Iran. This study shows that the DAT1 distribution in Iran has a different pattern from those in other studies, which can contribute to an understanding of differentiation and diversity of Iranian ethnic groups. This polymorphism could represent the genetic diversity among the various ethnic groups of Iran. Am. J. Hum. Biol., 2007. © 2007 Wiley‐Liss, Inc

Allele · Allele frequency · Biology · Dopamine transporter · Ethnic group · Gene · Genetic diversity · Genotype · Genotyping · Hum · Population · Sociology · Transporter · Anthropology · Autism Spectrum Disorder Research · Demography · Genetics and Neurodevelopmental Disorders · History · Neurotransmitter Receptor Influence on Behavior · Genetics

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