New studies of second and fourth digit ratio as a morphogenetic trait in subjects with congenital adrenal hyperplasia

Bibliographic Data

ID19459271
AuthorsMaria Prates Rivas (0000-0002-0637-6100, Universidade Federal da Bahia), Lília Maria De Azevedo Moreira (0000-0001-9768-3466, Universidade Federal da Bahia, corresponding author), Layla D E Santo (Universidade Federal da Bahia), Alexandre C S S Marques (0000-0001-5230-8793, Universidade Federal da Bahia), Charbel El-Hani (Universidade Federal da Bahia), C N El‐Hani (Department of General Biology Institute of Biology, Federal University of Bahia Salvador Brazil 40170‐290), Maria Betânia Pereira Toralles (0000-0001-7970-7102, Universidade Federal da Bahia)
Year2014
Volume26
Issue4
Pages559-561
Publication date2014-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.22545
PMID24668932
OpenAlexW1942042279
LanguageEN
Citations received7
References cited22

OBJECTIVES: Congenital adrenal hyperplasia (CAH) is a disease that occurs during fetal development and can lead to virilization in females or death in newborn males if not discovered early in life. Because of this there is a need to seek morphological markers in order to help diagnose the disease. In order to test the hypothesis that prenatal hormones can affect the sexual dimorphic pattern 2D:4D digit ratio in individual with CAH, the aim of this study was to compare the digit ratio in female and male patients with CAH and control subjects. METHODS: The 2D:4D ratios in both hands of 40 patients (31 females-46, XX, and 9 males-46, XY) were compared with the measures of control individuals without CAH (100 males and 100 females). RESULTS: Females with CAH showed 2D:4D ratios typical of male controls (0.950 and 0.947) in both hands (P < 0.001). In CAH males the left hand 2D:4D ratio (0.983) was statistically different from that of male controls (P < 0.05). CONCLUSIONS: These finding support the idea that sexual dimorphism in skeletal development in early fetal life is associated with differences between the exposure to androgens in males and females, and significant differences associated with adrenal hyperplasia. Although the effects of prenatal androgens on skeletal developmental are supported by numerous studies, further investigation is yet required to clarify the disease and establish the digit ratio as a biomarker for CAH

Androgen · Biology · Congenital adrenal hyperplasia · Digit ratio · Disease · Fetus · Hormone · Hyperplasia · Pregnancy · Sex ratio · Sexual differentiation · Sexual dimorphism · Virilization · Intestinal Malrotation and Obstruction Disorders · Medicine · Prenatal Screening and Diagnostics · Sexual Differentiation and Disorders · Endocrinology · Internal Medicine · Physiology

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