Prenatal testosterone of progenitors could be involved in the etiology of both anorexia nervosa and autism spectrum disorders of their offspring
Bibliographic Data
| ID | 19459455 |
|---|---|
| Authors | Ángel Romero‐martínez (0000-0002-5922-0265, Psychobiology Department University of Valencia Valencia Spain), Luis Moya‐albiol (0000-0002-2294-4147, Psychobiology Department University of Valencia Valencia Spain, corresponding author) |
| Year | 2014 |
| Volume | 26 |
| Issue | 6 |
| Pages | 863-866 |
| Publication date | 2014-11-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajhb.22597 |
| PMID | 25130276 |
| OpenAlex | W1827863444 |
| Language | EN |
| Citations received | 1 |
| References cited | 17 |
OBJECTIVES: High intrauterine testosterone (T) levels seem to play a role in the development of autism spectrum disorders (ASDs), but their role in anorexia nervosa (AN) is controversial. Parents with masculinized 2D:4D ratios, a marker of the organizational effects of T, may have other relevant biological characteristics, in particular exposing their offspring to high T levels in the prenatal environment. This would increase the likelihood of their offspring developing these disorders. METHODS: The present study examined whether parents of offspring with AN (n=34; mean age= 51) and ASD (n=36; mean age=45) differ from control parents (n=40; mean age=43) in 2D:4D ratio, as well as by salivary T levels and its relationships. RESULTS: Our results revealed that AN and ASD parents (fathers and mothers) have masculinized 2D:4D ratios of the right hand compared to control parents. However, the difference compared to controls was larger in the ASD than the AN group. Furthermore, current salivary T levels were negatively related to the 2D:4D ratio in ASD and AN parents only. CONCLUSIONS: Our data partially support the view of high prenatal masculinization as a potential intermediate phenotype to the development of these disorders in their offspring
Anorexia nervosa · Autism · Autism spectrum disorder · Biology · Developmental psychology · Digit ratio · Eating disorders · Etiology · Hum · Offspring · Pregnancy · Autism Spectrum Disorder Research · Clinical Psychology · Eating Disorders and Behaviors · Medicine · Psychology · Sexual Differentiation and Disorders · Endocrinology · Genetics · Internal Medicine · Physiology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.14 |
| Citation span | 2019 - 2019 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |