Cardiovascular factors explain genetic background differences in VO 2 max
Bibliographic Data
| ID | 19459678 |
|---|---|
| Authors | Jane L P Roy (University of Alabama at Birmingham, corresponding author), Gary R Hunter (0000-0002-5015-242X, University of Alabama at Birmingham), Jose R Fernandez (0000-0001-7509-6666, University of Alabama at Birmingham), John P Mccarthy (0000-0002-5776-6264, University of Alabama at Birmingham), D Enette Larson‐Meyer (0000-0001-9695-5474, University of Alabama at Birmingham), Tamilane E Blaudeau (University of Alabama at Birmingham), Bradley R Newcomer (0000-0002-8268-1721, University of Alabama at Birmingham) |
| Year | 2006 |
| Volume | 18 |
| Issue | 4 |
| Pages | 454-460 |
| Publication date | 2006-07-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajhb.20509 |
| PMID | 16788902 |
| OpenAlex | W2017590854 |
| Language | EN |
| References cited | 32 |
The purpose of this study was to further explore factors that may be related to ethnic differences in the maximum rate at which an individual can consume oxygen (VO 2 max) between 20 African American (AA) and 30 European American (EA) sedentary women who were matched for body weight (kg) and fat‐free mass (FFM). VO 2 max (l/min) was determined during a graded treadmill exercise test. Submaximal steady‐state heart rate and submaximal VO 2 were determined at a treadmill speed of 1.3 m/sec and a 2.5% grade. Hemoglobin (Hb) was determined by the cyanide method, muscle oxidative capacity by 31 P magnetic resonance spectroscopy (ADP time constant), and FFM (kg) by dual‐energy x‐ray absorptiometry. Genetic classification was self‐reported, and in a subset of the sample (N = 32), the determinants of ethnicity were measured by African genetic admixture. AA women had significantly reduced VO 2 max, Hb levels, and muscle oxidative capacity (longer ADP time constants, P ≤ 0.05) than EA women. Submaximal oxygen pulse (O 2 Psubmax), ADP time constant, Hb, and ethnic background were all significantly related to VO 2 max (ml/kg/min and ml/kg FFM/min, all P ≤ 0.01). By multiple regression modeling, Hb, O 2 Psubmax, muscle oxidative capacity, and ethnicity were found to explain 61% and 57% of the variance of VO 2 max in ml/kg/min and ml/kg FFM/min, respectively. Muscle oxidative capacity and O 2 Psubmax were both significantly and independently related to VO 2 max in all three models ( P ≤ 0.05), whereas Hb and ethnicity were not. These results suggest that mitochondrial muscle oxidative capacity and oxygen delivery capabilities, as determined by O 2 Psubmax, account for most if not all of the ethnic differences in VO 2 max. Am. J. Hum. Biol. 18:454–460, 2006. © 2006 Wiley‐Liss, Inc
Animal science · Biology · Blood pressure · Heart rate · Oxidative phosphorylation · Treadmill · VO2 max · Cardiovascular and exercise physiology · Chemistry · Genetics and Physical Performance · Medicine · Sports Performance and Training · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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