Association between insulin‐like growth factor‐1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north‐west province, South Africa
Bibliographic Data
| ID | 19459712 |
|---|---|
| Authors | Ramoteme L Mamabolo (Centre of Excellence for Nutrition North‐West University Potchefstroom 2520 South Africa), Cristiana Berti (0000-0002-4591-0791, Centre of Excellence for Nutrition North‐West University Potchefstroom 2520 South Africa), Makama Andries Monyeki (0000-0002-4156-8394, North-West University), Herculina S Kruger (0000-0002-5365-1777, North-West University, corresponding author) |
| Year | 2014 |
| Volume | 26 |
| Issue | 2 |
| Pages | 189-197 |
| Publication date | 2014-03-04 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 1042-0533 • E-ISSN: 1520-6300 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajhb.22498 |
| PMID | 24375890 |
| OpenAlex | W1556504537 |
| Language | EN |
| References cited | 56 |
OBJECTIVE: To determine if insulin-like growth factor-1 (IGF-1) is a significant predictor of body fat percentage (%BF), lean body mass, and insulin resistance (IR) in black adolescents presenting with overnutrition and undernutrition. METHODS: A cross-sectional study was undertaken in 181 adolescents (111 girls, 70 boys, 13-20 years old) from a low socio-economic population in the North-West Province, South Africa. Anthropometric measurements were performed, and %BF and lean mass were assessed by air displacement plethysmography. Serum glucose, leptin, insulin, IGF-1 and IGF-binding protein-3 (IGFBP-3) were measured and homeostasis model assessment of IR (HOMA-IR) was calculated. Predictors of body composition and HOMA-IR were determined in multivariate linear regressions. RESULTS: Of the boys, 31% had a %BF >20%, whereas 42% of girls had a %BF >30%. Furthermore, 17.1% male and 18.9% female adolescents were stunted, indicating overnutrition and undernutrition in the same group. IGF-1 showed a negative association with %BF in both sexes, and a positive correlation with height-for-age z-score (HAZ) and lean mass, respectively, in the boys. IGF-1 correlated positively and physical activity correlated negatively with fasting insulin and HOMA-IR in the girls. In both sexes, leptin had the strongest association with %BF in multiple regressions. Leptin and Tanner stage were significant predictors of HOMA-IR in girls, but not in boys. CONCLUSIONS: IGF-1 was positively associated with lean mass and HAZ in boys, indicating a beneficial relationship with linear growth, but with IR in the girls, indicating possible adverse metabolic effects in the presence of high %BF and physical inactivity
Insulin · Insulin resistance · Malnutrition · Overnutrition · Body Composition Measurement Techniques · Growth Hormone and Insulin-like Growth Factors · Medicine · Obesity, Physical Activity, Diet · Endocrinology · Internal Medicine
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| Highly cited | No |
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