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X‐linked pattern of inheritance for serial measures of weight/stature 2

Bibliographic Data

ID19460411
AuthorsPamela J Byard, Irène Sadowska Guillón (corresponding author), Roger M Siervogel, Alex F Roche
Year1989
Volume1
Issue4
Pages443-449
Publication date1989-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.1310010406
OpenAlexW28514110
LanguageEN
Citations received3
References cited19

The pattern of family resemblance for long‐term serial measures of weight/stature 2 (W/S 2 ) in approximately 500 individuals from the Fels Longitudinal Growth Study suggests that X‐linked genes may be contributing to the variability in this trait among children, particularly during the prepubertal age range of 2–9 years. In this data set, W/S 2 was measured serially at the same ages in all family members. Thus, a parent‐child correlation at a specific age can be determined even though the measurements were made on the child a generation later than on the parent. The pattern of family resemblance at each annual age up to 10 years and at ages 14–18 years is consistent with the presence of an X‐linked genetic effect. Opposite‐sex parent‐child pairs are more similar than same‐sex pairs, and sister‐sister pairs are more similar than brother‐brother or brother‐sister pairs at these ages. Furthermore, when the distribution of W/S 2 is examined separately in boys and girls, there is evidence of commingling in the distribution of boys from 5 to 8 years of age but not in girls. This is consistent with the existence of a major X‐linked gene with a frequency of about 3%. This pattern of family resemblance and commingling suggestive of partial X‐linkage for W/S 2 has not been detected previously because cross‐sectional family studies generally compare individuals at different stages of growth

Art · Humanities · Arts and Performance Studies · Physical Education and Sports Studies · Sociology and Education in Brazil

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Unique citing works3
Citations per year0.09
Citation span1991 - 2002 (12)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 2

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