The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea

Bibliographic Data

ID19460873
AuthorsWanhyung Lee (0000-0001-6408-7668, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), J H Yoon (0000-0003-4198-2955, Korea Institute for Health and Social Affairs), Jin‐ha Yoon (Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Jaehoon Roh (0000-0003-4228-7209, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Seunghyun Lee (0000-0001-5427-1023, Korea Institute for Health and Social Affairs), S-W LEE (0009-0006-1135-4586, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Hongdeok Seok (0000-0002-4202-2617, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), June‐hee Lee (0000-0002-7682-6023, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Pil Kyun Jung (0000-0001-6559-2172, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Jeongbae Rhie (0000-0002-2748-6835, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea), Jong‐uk Won (0000-0002-9200-3297, Department of Preventive Medicine The Institute for Occupational Health Seoul South Korea, corresponding author)
Year2016
Volume28
Issue5
Pages729-735
Publication date2016-09-10
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Human Biology (JOURNAL)
Journal identifiersISSN: 1042-0533 • E-ISSN: 1520-6300
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajhb.22857
PMID27121332
OpenAlexW2342791414
LanguageEN
Citations received1
References cited42

OBJECTIVES: Low-level lead exposure has been associated with increases in blood pressure (BP) and impairment of the cardiovascular system. Prehypertension is not categorized as a disease currently; however, individuals with untreated prehypertension are known to be at increased risk of progression to hypertension and mortality caused by cardiovascular disease. We investigated the association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults. METHODS: A total of 8,493 participants (3,945 men and 4,548 women) were included in the current analysis, using data from the fourth, fifth, and sixth Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2013. Blood analysis, self-report questionnaires, and physical examinations were used to assess blood lead levels, BP, and medical history. Odds ratios (OR) and 95% confidence intervals (95% CI) for prehypertension were calculated using multiple logistic regression models. RESULTS: Compared to the first quartile (Q1) blood lead level (0.206-1.539 μg/dl), the ORs (95% CI) were 1.24 (1.04-1.48) in Q2, (1.540-2.056 μg/dl), 1.27 (1.06-1.52) in Q3, (2.057-2.716 μg/dl), and 1.30 (1.07-1.60) in Q4 (2.717-24.532 μg/dl) for the prevalence of prehypertension after adjusting for age, sex, morbidity status, socioeconomic status, and health behavioral variables. CONCLUSIONS: Our large, cross-sectional, nationwide study revealed that blood lead levels below the threshold for the harmful effects of lead were significantly associated with prehypertension. Am. J. Hum. Biol. 28:729-735, 2016. © 2016 Wiley Periodicals, Inc

Blood lead level · Blood pressure · Confidence interval · Cross-sectional study · Environmental health · Lead exposure · Logistic regression · National Health and Nutrition Examination Survey · Odds ratio · Pathology · Population · Prehypertension · Quartile · Heavy Metal Exposure and Toxicity · Medicine · Sodium Intake and Health · Trace Elements in Health · Internal Medicine

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